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Scientific Publications / Calcium & Health - Cancer
Scientific Publications / Calcium & Health - Cancer
Scientific Publications / Calcium & Health - Cancer

   

  1. Cancer Health Claims
  2. High Blood Pressure Health Claims

  3. Kidney Stones Health Claims

  4. Bone Fractures Health Claims

  5. Menstrual Disorders Health Claims

 

LITERATURE CITED for Calcium and
Cancer Health Claims

NOTE:  The lists share many of the same publications.

  1. Bronner F. Intestinal calcium absorption: Mechanisms and applications. J Nutr 1987;117:1347-1352.
  2. Peng JB, Chen XZ, Berger UV, Vassilev PM, Tguchi H, Brown EM, Hediger MA. Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. J Biol Chem 1999;274:22739-22746.
  3. Zhuang L, Peng JB, Tou L, Takanaga H, Adam RM, Hediger MA, Freeman MR. Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies. Lab Invest 2002;82:1755-1764.
  4. Fleet JC, Wood RJ. Specific 1,25(OH)2D3-mediated regulation of transcellular calcium transport in Caco-2 cells. Am J Physiol 1999;276:G958-G964.
  5. Barger-Lux MJ, Heaney RP, Recker RR. Time course of calcium absorption in humans: Evidence for a colonic component. Calcif Tissue Int 1989;44:308-311.
  6. Cashman K. Prebiotics and calcium bioavailability. Curr Issues Intest Microbiol 2003;4:21-32.
  7. Ireland P, Fordtran JS. Effect of dietary calcium and age on jejunal calcium absorption in humans studied by intestinal perfusion. J Clin Invest 1973;52:2672-2681.
  8. Gallagher JC, Riggs BL, DeLuca HF. Effect of estrogen on calcium absorption and serum vitamin D metabolites in postmenopausal osteoporosis. J Clin Endocrinol Metab 1980;51:1359-1364.
  9. Heaney RP, Saville PD, Recker RR. Calcium absorption as a function of calcium intake. J Lab Clin Med 1975;85:881-890.
  10. Heaney RP, Recker RR, Stegman MR, Moy AJ. Calcium absorption in women: Relationships to calcium intake, estrogen status, and age. J Bone Min Res 1989;4:469-475.
  11. Heaney RP, Weaver CM, Fitzsimmons ML. Influence of calcium load on absorption fraction. J Bone Min Res 1990;5:1135-1138.
  12. Abrams SA, Wen J, Stuff JE. Absorption of calcium, zinc and iron from breast milk by five-to seven-month-old infants. Pediatr Res 1996;39:384-390.
  13. Heaney RP. Effect of calcium on skeletal development, bone loss, and risk of fractures. Am J Med. 1991 Nov 25;91(5B):23S-28S.
  14. Bullamore JR, Wilkinson R, Gallagher JC, Nordin BEC, Marshall DH. Effects of age on calcium absorption. Lancet 1970;ii:535-537.
  15. Wolf RL, Cauley JA, Baker CE, Ferrell RE, Charron M, Cag AW, Salamone LM, Heaney RP, Kuller LH. Factors associated with calcium absorption efficiency in pre- and perimenopausal women. Am J Clin Nutr. 2000;72):466-471.
  16. Pattanaungkul S, Riggs BL, Yergey AL, Vieira NE, O'Fallon WM, Khosla S. Relationship of intestinal calcium absorption to 1,25-dihydroxyvitamin D [1,25(OH)2D] levels in young versus elderly women: Evidence for age-related intestinal resistance to 1,25(OH)2D action. J Clin Endocrinol Metab 2000;85:4023-4027.
  17. Abrams SA, Silber TJ, Esteban NV, Vieira NE, Stuff JE, Meyers R, Majd M, Yergey AL. Mineral balance and bone turnover in adolescents with anorexia nervosa. J Pediatr 1993;123:326-331.
  18. Abrams SA, O'Brien KO, Stuff JE. Changes in calcium kinetics associated with menarche. J Clin Endocrinol Metab 1996;81:2017-2020.
  19. Farmer ME, White LR, Brody JA, Bailey KR. Race and sex differences in hip fracture incidence. Am J Public Health 1984;74:1374-1380.
  20. Kellie SE, Brody JA. Sex-specific and race-specific hip fracture rates. Am J Pub Health 1990;80:326-328.
  21. Dawson-Hughes B, Harris S, Kramich C, Dallal G, Rasmussen HM. Calcium retention and hormone levels in black and white women on high- and low-calcium diets. J Bone Min Res 1993;8:779-787.
  22. Drinkwater B, Bruemner B, Chestnut C. Menstrual history as a determinant of current bone density in young athletes. JAMA 1990;263:545-548.
  23. Marcus R, Cann C, Madvig P, Minkoff J, Goddard M, Bayer M, Martin M, Gaudiani L, Haskell W, Genant H. Menstrual function and bone mass in elite women distance runners. Endocrine and metabolic features. Ann Intern Med 1985;102:158-163.
  24. Berkelhammer CH, Wood RJ, Sitrin MD. Acetate and hypercalciuria during total parenteral nutrition. Am J Clin Nutr 1988;48:1482-1489.
  25. Sebastian A, Harris ST, Ottaway JH, Todd KM, Morris RC Jr. Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate. N Engl J Med 1994;330:1776-1781.
  26. Bell NH, Yergey AL, Vieira NE, Oexmann MJ, Shary JR. Demonstration of a difference in urinary calcium, not calcium absorption, in black and white adolescents. J Bone Min Res 1993;8:1111-1115.
  27. Spencer H, Kramer L, Lensiak M, DeBartolo M, Norris C, Osis D. Calcium requirements in humans. Report of original data and a review. Clin Orthop Related Res 1984;184:270-280.
  28. Jackman LA, Millane SS, Martin BR, Wood OB, McCabe GP, Peacock M, Weaver CM. Calcium retention in relation to calcium intake and postmenarcheal age in adolescent females. Am J Clin Nutr 1997;66:327-333.
  29. Institute of Medicine. Calcium. In: Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. National Academy Press, Washington, DC, 1997, chapter IV.
  30. Miller K, Waye JD. Colorectal polyps in the elderly: What should be done? Drugs Aging 2002;19:393-404.
  31. American Cancer Society. Cancer Facts and Figures 2002. (44 pages) http://www.cancer.org.
  32. Turini ME, DuBois RN. Primary prevention: Phytoprevention and chemoprevention of colorectal cancer. Hematol Oncol Clin North Am 2002;16:811-840.
  33. Potter JD. Nutrition and colorectal cancer. Cancer Causes Control 1996;7:127-146.
  34. Marilley D, Vonlanthen S, Gioria A, Schwaller B. Calretinin and calretinin-22k increase resistance toward sodium butyrate-induced differentiation in CaCo-2 colon adenocarcinoma cells. Exp Cell Res 2001;268:93-103.
  35. Gordon JI, Schmidt GH, Roth KA. Studies of intestinal stem cells using normal, chimeric and transgenic mice. FASEB J 1992;6:3039-3050.
  36. Eastwood GL. A review of gastrointestinal epithelial renewal and its relevance to the development of adenocarcinomas of the gastrointestinal tract. J Clin Gastroenterol 1995;21(Suppl. 1):S1-S11.
  37. Schmidt GH, Wilkinson MM, Ponder BA. Cell migration pathway in the intestinal epithelium: An in situ marker system using mouse aggregation chimeras. Cell 1985;40:425-429.
  38. Wright NA, Irwin M. The kinetics of villus cell populations in the mouse small intestine. I. Normal villi: The steady state requirement. Cell Tissue Kinet 1982;15:595-609.
  39. Whitfield JF, Bird RP, Chakravarthy BR, Isaacs RJ, Morley P. Calcium - Cell cycle regulator, differentiator, killer, chemopreventor, and maybe, tumor promoter. J Cell Biochem Suppl 1995;22:74-91.
  40. Kerr JFR, Wyllie AH, Currie AR. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239-257.
  41. Arends MJ, Wyllie AH. Apoptosis: Mechanisms and roles in pathology. Int Rev Exp Pathol 1991;32:223-254.
  42. Patel T, Gores GJ, Kaufmann SH. The role of proteases during apoptosis. FASEB J 1996;10:587-597.
  43. Arends MJ, Morris RG, Wyllie AH. Apoptosis: The role of the endonuclease. Am J Pathol 1990;136:593-608.
  44. Duke RC, Chervenak R, Cohen JJ. Endogenous endonuclease induced DNA fragmentation: An early event in cell mediated cytolysis. Proc Natl Acad Sci USA 1983;80:6361-6365.
  45. Cohen JJ, Duke RC. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J Immunol 1984;132:38-42.
  46. Furuya Y, Lundmo P, Short AD, Gill DL, Isaacs JT. The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin. Cancer Res 1994;54:6167-6175.
  47. Trump BF, Berezesky IK. The role of altered [Ca2+]i regulation in apoptosis, oncosis, and necrosis. Biochim Biophys Acta 1996;1313:173-178.
  48. Sundaram SG, Milner JA. Diallyl disulfide induces apoptosis of human colon tumor cells. Carcinogenesis 1996;17:669-673.
  49. Raff M. Cell suicide for beginners. Nature 1998;396:119-122.
  50. Richter C. Pro-oxidants and mitochondrial Ca2+: Their relationship to apoptosis and oncogenesis. FEBS Lett 1993;325:104-107.
  51. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA, Brenner DA, Herman B. The mitochondrial permeability transition in cell death: A common mechanism in necrosis, apoptosis and autophagy. Biochem Biophys Acta 1998;1366:177-196.
  52. Zamzami N, Kroemer G. The mitochondrion in apoptosis: How Pandora's box opens. Nat Rev Mol Cell Biol 2001;2:67-71.
  53. Krishnan K, Brenner DE. Chemoprevention of colorectal cancer. Gastroenterol Clin North Am 1996;25:821-858.
  54. Sporn MB. Approaches to prevention of epithelial cancer during the preneoplastic period. Cancer Res 1976;36:2699-2702.
  55. Gwyn K, Sinicrope FA. Chemoprevention of colorectal cancer. Am J Gastroenterol 2002;97:13-21.
  56. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759-767.
  57. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smits AMM, Bos JL. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-532.
  58. Fearon ER, Cho KR, Nigro JM, Kern SE, Simons JW, Ruppert JM, Hamilton SR, Preisinger AC, Thomas G, Kinzler K, Vogelstein B. Identification of a chromosome 18q gene that is altered in colorectal cancer. Science 1990;247:49-56.
  59. Issa JPJ, Vertino PM, Wui J, Sazawal S, Celano P, Nelkin BD, Hamilton SR, Baylin SB. Increased cytosine DNA-methyltransferase activity during colon cancer progression. JNCI 1993;85:1235-1240.
  60. Goelz SE, Vogelstein B, Hamilton SR, Feinberg AP. Hypomethylation of DNA from benign and malignant human human colon neoplasms. Science 1985;228:187-190.
  61. Feinberg AP, Gehrke CW, Kuo KC, Ehrlich M. Reduced genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res 1988;48:1159-1161.
  62. Spencer CA, Groudine M. Control of c-myc regulation in normal and neoplastic cells. Advanc Cancer Res 1990;56:1-48.
  63. Melhem MF, Meisler AI, Finley GG, Bryce WH, Jones MO, Tribby II, Pipas JM, Koski RA. Distribution of cells expressing myc proteins in human colorectal epithelium, polyps and malignant tumors. Cancer Res 1992;52:5853-5864.
  64. Forgue-Lafitte M-E, Coudray A-M, Breant B, Mester J. Proliferation of the Caco-2 human colon-carcinoma cell line HT-29: Autocrine growth and deregulated expression of the c-myc oncogene. Cancer Res 1989;49:6566-6571.
  65. Bodmer WF, Bailey CJ, Bodmer J, Bussey HJR, Ellis A, Gorman P, Lucibello FC, Murday VA, Rider SH, Scambler P, Sheer D, Solomon E, Spurr NK. Localization of the gene for familial adenomatous polyposis in chromosome 5. Nature 1987;328:614-616.
  66. Leppert M, Dobbs M, Scambler P, O'Connell P, Nakamura Y, Stauffer D, Woodward S, Burt R, Hughes J, Gardner E, Lathrop M, Wasmuth J, Lalouel J-M, White R. The gene for familial polyposis coli maps to the long arm of chromosome 5. Science 1987;238:1411-1413.
  67. Groden J, Thliveris A, Samowitz W, Carlson M, Gelbert L, Albertsen H, Joslyn G, Stevens J, Spirio L, Robertson M, Sargeant L, Krapcho K, Wolff E, Burt R, Hughes JP, Warrington J, McPherson J, Wasmuth J, Le Paslier D, Abderrahim H, Cohen D, Leppert M, White R. Identification and characterization of the familial adenomatous polyposis coli gene. Cell 1991;66:589-600.
  68. Nathke IS, Adams CL, Polakis P, Sellin JH, Nelson WJ. The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J Cell Biol 1996;134:165-179.
  69. Barth AI, Nathke IS, Nelson WJ. Cadherins, catenins and APC protein: Interplay between cytoskeletal complexes and signaling pathways. Curr Opinions Cell Biol 1997;9:683-690.
  70. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87:159-170.
  71. Potter JD. Colorectal cancer: Molecules and populations. J Natl Cancer Inst 1999;91:916-932.
  72. Houlston RS. What we could do now: Molecular pathology of colorectal cancer. J Clin Pathol Mol Pathol 2001;54:206-214.
  73. Bartram H-P, Scheppach W, Schmid H, Hofmann A, Dusel G, Richter F, Richter A, Kasper H. Proliferation of human colonic mucosa as an intermediate biomarker of carcinogenesis: Effects of butyrate, deoxycholate, calcium, ammonia, and pH. Cancer Res 1993;53:3283-3288.
  74. Govers MJ, Termont DS, Van der Meer R. Mechanism of the antiproliferative effect of milk mineral and other calcium supplements on colonic epithelium. Cancer Res 1994;54:95-100.
  75. Newmark HL, Lipkin M, Maheshwari N. Colonic hyperproliferation induced in rats and mice by nutritional-stress diets containing four components of a human Western-style diet (Series 2). Am J Clin Nutr 1991;54:209s-214s.
  76. Bird RP, Schneider R, Stamp D, Bruce WR. Effect of dietary calcium and cholic acid on the proliferative indices of murine colonic epithelium. Carcinogenesis 1986;7:1657-1661.
  77. Wargovich MJ, Eng VWS, Newmark HL, Bruce WR. Calcium ameliorates the toxic effect of deoxycholic acid on colonic epithelium. Carcinogenesis 1983;4:1205-1207.
  78. Wargovich MJ, Eng VWS, Newmark HL. Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colon epithelium. Cancer Lett 1984;23:253-258.
  79. McLellan EA, Bird RP. Aberrant crypts: Potential preneoplastic lesions in the murine colon. Cancer Res 1988;48:6187-6192.
  80. Bird RP. Observations and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: Preliminary findings. Cancer Lett 1987;37:147-151.
  81. Correa P. Epidemiology of polyps and cancer. Major Prob Pathol 1978;10:126-152.
  82. Hill MJ. Etiology of the adenoma-carcinoma sequence. Major Prob Pathol 1978;10:153-162.
  83. Kendall CW, Janezic SA, Friday D, Venket Rao A. Dietary cholesterol enhances preneoplastic aberrant crypt formation and alters cell proliferation in the murine colon treated with azoxymethane. Nutr Cancer 1992;17:107-114.
  84. Magnuson BA, Carr I, Bird RP. Ability of aberrant crypt characteristics to predict colonic tumour incidence in rats fed cholic acid. Cancer Res 1993;53:4499-4504.
  85. Pretlow TP, Barrow BJ, Ashton WS, O'Riordan MA, Pretlow TG, Jurcisek JA, StellatoTA. Aberrant crypts: Putative preneoplastic foci in human colonic mucosa. Cancer Res 1991;51:1564-1567.
  86. Pretlow TP, O'Riordan MA, Somich GA, Amini SB, Pretlow TG. Aberrant crypts correlate with tumour incidence in F344 rats treated with azoxymethane and phytate. Carcinogenesis 1992;13:1509-1512.
  87. Rao CV, Desai D, Simi B, Kulkarni N, Amin S, Reddy BS. Inhibitory effect of caffeic acid esters on azoxymethane-induced biochemical changes and aberrant crypt foci formation in rat colon. Cancer Res 1993;53:4182-4188.
  88. Shivapurkar N, Tang ZC, Frost A, Alabaster O. Inhibition of progression of aberrant crypt foci and colon tumour development by vitamin E and ß-carotene in rats on a high-risk diet. Cancer Lett 1995;91:125-132.
  89. Zarkovic M, Qin X, Nakatsuru Y, Oda H, Nakamura T, Shamsuddin AM, Ishikawa T. Tumour promotion by fecapentaene-12 in a rat colon carcinogenesis model. Carcinogenesis 1993;14:1261-1264.
  90. Höpfner M, Lemmer K, Jansen A, Hanski C, Riecken E-O, Gavish M, Mann B, Buhr H, Glassmeier G, Scherübl H. Expression of functional P2-purinergic receptors in primary cells cultures of human colorectal carcinoma cells. Biochem Biophys Res Commun 1998;251:811-817.
  91. Höpfner M, Maaser K, Barthel B, von Lampe B, Hanski C, Riecken E-O, Zeitz M, Scherubl H. Growth inhibition and apoptosis induced by P2Y2 receptors in human colorectal carcinoma cells: Involvement of intracellular calcium and cyclic adenosine monophosphate. Int J Colorectal Dis 2001;16:154-166.
  92. Harden TK, Boyer JL, Nicholas RA. P2-purinergic receptors: Subtype-associated signaling responses and structure. Annu Rev Pharmacol Toxicol 1995;35:541-579.
  93. Lustig KD, Conklin BR, Herzmark P, Taussig R, Bourne HR. Type II adenylylcyclase integrates coincident signals from Gs, Gi and Gq. J Biol Chem 1993;268:13900-13905.
  94. Farese RV. Calcium as an intracellular mediator of hormone action: Intracellular phospholipid signaling systems. Am J Med Sci 1988;296:223:230.
  95. Whitfield JF, Boynton AL, Macmanus JP, Sikorska M, Tsang BK. The regulation of cell proliferation by calcium and cyclic AMP. Mol Cell Biochem 1979;27:155-179.
  96. Weiss H, Amberger A, Widschwendter M, Margreiter R, Ofner D, Dietl P. Inhibition of store-operated calcium entry contributes to the anti-proliferative effect of non-steroidal anti-inflammatory drugs in human colon cancer cells. Int J Cancer 2001;92:877-882.
  97. Korczak B, Whale C, Kerbel RS. Possible involvement of Ca2+ mobilization and protein kinase C activation in the induction of spontaneous metastasis by mouse mammary adenocarcinoma. Cancer Res 1989;49:2597-2560.
  98. Liu B, Renaud C, Nelson KK, Chen YQ, Bazaz R, Kowynia J, Timar J, Diglio CA, Honn KV. Protein kinase C inhibitor calphostin C reduces B16 amelanotic melanoma cell adhesion to endothelium and lung colonization. Int J Cancer 1992;52:147-152.
  99. Amstad PA, Krupitza G, Cerutti PA. Mechanism of c-fos induction by active oxygen. Cancer Res 1992;52:3952-3960.
  100. Kelloff GJ, Crowell JA, Steele VE, Lubet RA, Boone CW, Malone WA, Hawk ET, Lieberman R, Lawrence JA, Kopelovich L, Ali I, Viner JL, Sigman CC. Progress in cancer chemoprevention. Ann N Y Acad Sci 1999;889:1-13.
  101. Fischer SM, Lee ML, Maldve RE, Morris RJ, Trono D, Burrow DL, Butler AP, Pavone A, Warren B. Association of protein kinase C activation with induction of ornithine decarboxylase in murine but not human keratinocytes cultures. Mol Carcinog 1993;7:228-237.
  102. Klein IK, Ritland SR, Burgart LJ, Ziesmer SC, Roche PC, Gendler SJ, Karnes WE Jr. Adenoma-specific alterations of protein kinase C isozyme expression in APCmin mice. Cancer Res 2000;60:2077-2080.
  103. Stauble B, Boscoboinik D, Tasinato A, Azzi A. Modulation of activator protein-1 (AP-1) transcription factor and protein kinase C by hydrogen peroxide and a-tocopherol in vascular smooth muscle cells. Eur J Biochem 1994;226:393-402.
  104. Russell DH. Ornithine decarboxylase: A key regulatory enzyme in normal and neoplastic growth. Drug Metab Rev 1981;16:1-88.
  105. Janne J, Poso H, Raina A. Polyamines in rapid growth and cancer. Biochem Biophys Acta 1978;473:241-293.
  106. Williams-Ashman HG, Canellakis ZN. Polyamines in mammalian biology and medicine. Perspect Biol Med 1979;2:421-453.
  107. Pegg AE. Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. Cancer Res 1988;48:759-774.
  108. Luk GD, Baylin SB. Ornithine decarboxylase as a biologic marker in familial colonic polyposis. N Engl J Med 1984;311:80-83.
  109. Love RR, Verma AK, Surawicz TS, Morrissey JF. Absence of effect of supplemental oral calcium on ornithine decarboxylase (ODC) activity in colonic mucosae of healthy individuals with a family history of colorectal cancer. J Surg Oncol. 1990 Feb;43(2):79-82.
  110. Hibshoosh H, Johnson M, Weistein IB. Effects of overexpression of ornithine decarboxylase (ODC) on growth control and oncogene-induced cell transformation. Oncogene 1991;6:739-743.
  111. Ishizuka J, Bold RJ, Townsend CM Jr, Thompson JC. Role of calcium in the regulation of ornithine decarboxylase enzyme activity in mouse colon cancer cells. Cancer Invest 1995;13:181-187.
  112. Steele VE, Moon RC, Lubet RA, Grubbs CJ, Reddy BS, Wargovich M, McCormick DL, Pereira MA, Crowell JA, Bagheri D, Sigman CC, Boone CW, Kelloff GJ. Preclinical efficacy evaluation of potential chemopreventive agents in animal carcinogenesis models: Methods and results from the NCI Chemoprevention Drug Development Program. J Cell Biochem Suppl 1994;20:32-54.
  113. Jarvis WD, Turner AJ, Povirk LF, Taylor RS, Grant S. Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res 1994;54:1707-1714.
  114. Whelan RD, Parker PJ. Loss of protein kinase C function induces a proapoptotic response. Oncogene 1998;16:1939-1944.
  115. Hannun YA. Functions of ceramide in coordinating cellular responses to stress. Science 1996;274:1855-1859.
  116. Haimovitz-Friedman A, Kolesnick RN, Fuks Z. Ceramide signaling in apoptosis. Br Med Bull 1997;53:539-553.
  117. Bradham C, Quian T, Streetz K, Trautwein C, Brenner DA, Lemasters JJ. The mitochondrial permeability transition is required for tumor necrosis factor a-mediated apoptosis and cytochrome c release. Mol Cell Biol 1998;18:6353-6364.
  118. Chinnaiyan AM. The apoptosome: Heart and soul of the cell death machine. Neoplasia 1999;1:5-15.
  119. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: A primary site of Bcl-2 regulation of apoptosis. Science 1997;275:1132-1136.
  120. Kallay E, Bajna E, Wrba F, Kriwanek S, Peterlik M, Cross HS. Dietary calcium and growth modulation of human colon cancer cells: Role of the extracellular calcium-sensing receptor. Cancer Detect Prev 2000;24:127-136.
  121. Cross HS, Pavelka M, Slavik J, Peterlik M. Growth control of human colon cancer cells by vitamin D and calcium in vitro. J Natl Cancer Inst 1992;84:1355-1357.
  122. Lamprecht SA, Lipkin M. Chemoprevention of colon cancer by calcium, vitamin D and folate: Molecular mechanisms. Nat Rev Cancer 2003;3:601-614.
  123. Morotomi M, Guillem JG, Weinstein IB. Production of diacylglycerol, an activator of protein kinase C, by human intestinal microflora. Cancer Res 1990;50:3595-3599.
  124. Morotomi M, LoGerfo P, Weinstein IB. Fecal excretion, uptake and metabolism by colon mucosa of diacylglycerol in rats. Biochem Biophys Res Commun 1991;181:1028-1034.
  125. Friedman E, Isaksson P, Rafter J, Marian B, Winawer S, Newmark H. Fecal diglycerides as selective endogenous mitogens for premalignant and malignant human colonic epithelial cells. Cancer Res 1989;49:544-548.
  126. Craven PA, Pfanstiel J, DeRubertis, FR. Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation and reactive oxygen formation by bile acids. J Clin Invest 1987;79:532-541.
  127. Weinstein IB. Cancer prevention: Recent progress and future opportunities. Cancer Res 1991;51:5080-5085.
  128. Atillasoy E, Fein B, Weinstein IB, Holt PR. Fecal diacylglycerol concentrations and calcium supplementation. Cancer Epidemiol Biomarkers Prev 1995;4:795-796.
  129. Steinbach G, Lupton J, Reddy BS, Kral JG, Holt PR. Effect of calcium supplementation on rectal epithelial hyperproliferation in intestinal bypass subjects. Gastroenterology 1994;106:1162-1167.
  130. Holt PR, Moss SF, Whelan R, Guss J, Gilman J, Lipkin M. Fecal and rectal mucosal diacylglycerol concentrations and epithelial proliferative kinetics. Cancer Epidemiol Biomarkers Prev 1996;5:937-940.
  131. Tangpricha V, Flanagan JN, Whitlatch LW, Tseng CC, Chen TC, Holt PR, Lipkin MS, Holick MF. 25-hydroxyvitamin D-1a-hydroxylase in normal and malignant colon tissue. Lancet 2001;357:1673-1674.
  132. Cross HS, Bareis P, Hofer H, Bischof MG, Bajna E, Kriwanek S, Bonner E, Peterlik M. 25-Hydroxyvitamin D3-1a hydroxylase and vitamin D receptor gene expression in human colonic mucosa is elevated during early cancerogenesis. Steroids 2001;66:287-292.
  133. Zehnder D, Bland R, Williams MC, McNinch RW, Howie AJ, Stewart PM, Hewison M. Extrarenal expression of 25-hydroxyvitamin D3-1a hydroxylase. J Clin Endocrinol Metab 2001;86:888-894.
  134. Baron JA, Beach M, Mandel JS, van Stolk RU, Haile RW, Sandler RS, Rothstein R, Summers RW, Snover DC, Beck GJ, Frankl H, Bond JH, Greenberg ER. Calcium supplements and colorectal adenomas. Calcium Polyp Prevention Study Group. N Engl J Med 1999;340:101-107.
  135. Brenner BM, Russell N, Albrecht S, Davies RJ. The effect of dietary vitamin D3 on the intracellular calcium gradient in mammalian colonic crypts. Cancer Lett 1998;127:43-53.
  136. Holt PR, Arber N, Halmos B, Forde K, Kissileff H, McGlynn KA, Moss SF, Kurihara N, Fan K, Yang K, Lipkin M. Colonic epithelial cell proliferation decreases with increasing levels of serum 25-hydroxy vitamin D. Cancer Epidemiol Biomarkers Prev 2002;11:113-119.
  137. Holt PR, Atillasoy EO, Gilman J, Guss J, Moss SF, Newmark H, Fan K, Yang K, Lipkin M. Modulation of abnormal colonic epithelial cell proliferation and differentiation by low-fat dairy foods. A randomized controlled trial. JAMA 1998;280:1074-1079.
  138. Lointier P, Wargovich MJ, Saez S, Levin B, Wildrick DM, Boman BM. The role of vitamin D3 in the proliferation of a human colon cancer cell line in vitro. Anticancer Res 1987;7:817-821.
  139. Giuliano AR, Franceschi RT, Wood RJ. Characterization of the vitamin D receptor from the Caco-2 human colon carcinoma cell line: Effect of cellular differentiation. Arch Biochem Biophys 1990;285:261-269.
  140. Harper KD, Iozzo RV, Haddad JG. Receptors for and bioresponses to 1,25-dihydroxyvitamin D in a human colon carcinoma cell line (HT-29). Metabolism 1989;38:1062-1069.
  141. Suda T, Shinki T, Takashashi N. The role of vitamin D in bone and intestinal cell differentiation. Annu Rev Nutr 1990;10:195-211.
  142. Tanaka Y, Bush KK, Eguchi T, Ikekawa N, Taguchi T, Kobayashi Y, Higgins PJ. Effects of 1,25-dihydroxyvitamin D3 and its analogs on butyrate-induced differentiation of HT029 human colonic carcinoma cells and on the reversal of the differentiated phenotype. Arch Biochem Biophys 1990;276:415-423.
  143. Eisman JA, Barkla DH, Tutton PJM. Suppression of in vivo growth of human cancer solid tumor xenografts by 1,25-dihydroxyvitamin D3. Cancer Res 1987;47:21-25.
  144. Brehier A, Thomasset M. Human colon cell line HT-29: Characterization of 1,25-dihydroxyvitamin D3 receptor and induction of differentiation by the hormone. J Steroid Biochem 1988;29:265-270.
  145. Lointier P, Meggouh F, Dechelotte P, Pezet D, Ferrier C, Chipponi J, Saez S. 1,25-dihydroxyvitamin D3 receptors and human colon adenocarcinoma. Br J Surg 1991;78:435-439.
  146. Lointier P, Meggouh F, Pezet D, Dapoigny M, Dieng PND, Saez S, Chipponi J. Specific receptor for 1,25-dihydroxyvitamin D3 (1,25-DR) and human colorectal carcinogenesis. Anticancer Res 1989;9:1921-1924.
  147. Meggouh F, Lointier P, Saez S. Sex steroid and 1,25-dihydroxyvitamin D3 receptors in human colorectal adenocarcinoma and normal mucosa. Cancer Res 1991;51:1227-1233.
  148. Danes BS, De Angelis P, Traganos F, Melamed MR. Heritable colon cancer: Influence of increased calcium concentration on increased in vitro tetraploidy (IVT). Med Hypotheses 1991;36:69-72.
  149. Danes BS. Effect of increased calcium concentration on in vitro growth of human colonic mucosal lines. Dis Colon Rectum 1991;34:552-556.
  150. Buset M, Lipkin M, Winawer S, Swaroop S, Friedman E. Inhibition of human colonic epithelial cell proliferation in vivo and in vitro by calcium. Cancer Res 1986;46:5426-5430.
  151. Friedman E, Lipkin M, Winawer S, Buset M, Newmark H. Heterogeneity in the response of familial polyposis epithelial cells and adenomas to increasing levels of calcium in vitro. Cancer 1989;63:2486-2491.
  152. Buras RR, Shabahang M, Davoodi F, Schumaker LM, Cullen KJ, Byers S, Nauta RJ, Evans SRT. The effect of extracellular calcium on colonocytes: Evidence for differential responsiveness based upon degree of cell differentiation. Cell Prolif 1995;28:245-262.
  153. Cross HS, Hulla W, Tong W-M, Peterlik M. Growth regulation of human colon adenocarcinoma-derived cells by calcium, vitamin D and epidermal growth factor. J Nutr 1995;125:2004S-2008S.
  154. Wargovich MJ. Calcium and colon cancer. J Am Coll Nutr 1988;7:295-300.
  155. Kelloff GJ, Crowell JA, Boone CW, Steele VE, Lubet RA, Greenwald P, Alberts DS, Covey JM, Doody LA, Knapp GG, Nayfield S, Parkinson DR, Prasad VK, Prorok PC, Sausville EA, Sigman CC. Clinical development plan: Calcium. Chemoprevention Branch and Agent Development Committee. National Cancer Institute. J Cell Biochem Suppl 1994;20:86-109.
  156. Eshleman JR, Markowitz SD. Microsatellite instability in inherited and sporadic neoplasms. Curr Opin Oncol 1995;7:83-89.
  157. Thibodeau SN, Bren G, Schaid D. Microsatellite instability in cancer of the proximal colon. Science 1993;260:816-819.
  158. Tsao JL, Dudley S, Kwok B, Nickel AE, Laird PW, Siegmund KD, Liskay RM, Shibata D. Diet, cancer and aging in DNA mismatch repair deficient mice. Carcinogenesis 2002;23:1807-1810.
  159. Aaltonen LA, Peltomaki P, Leach FS, Sistonen P, Pylkkanen L, Mecklin J-P, Jarvinen H, Powell SM, Jen J, Hamilton SR, Petersen GM, Kinzler KW, Vogelstein B, de la Chapelle A. Clues to the pathogenesis of familial colorectal cancer. Science 1993;260:812-816.
  160. Marra G, Boland CR. Hereditary nonpolyposis colorectal cancer: The syndrome, the genes, and historical perspectives. J Natl Cancer Inst 1995;87:1114-1125.
  161. Peltomaki P, Vasen HF. Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer. Gastroenterolog 1997;113:1146-1158.
  162. van Aken E, De Wever O, Correia da Rocha AS, Mareel M. Defective E-cadherin/catenin complexes in human cancer. Virchows Arch 2001;439:725-751.
  163. Ilyas M, Tomlinson IPM. The interactions of APC, E-cadherin and ß-catenin in tumour development and progression. J Pathol 1997;182:128-137.
  164. Chakrabarty S, Radjendirane V, Appelman H, Varani J. Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of beta-catenin/TCF activation. Cancer Res 2003;63:67-71.
  165. Kallay E, Bonner E, Wrba F, Thakker RV, Peterlik M, Cross HS. Molecular and functional characterization of the extracellular calcium-sensing receptor in human colon cancer cells. Oncol Res 2003;13:551-559.
  166. Chattopadhyay N, Yamaguchi T, Brown EM. Ca2+ receptor from brain to gut: Common stimulus, diverse actions. Trends Endocrinol Metab 1998;9:354-359.
  167. Sheinin Y, Kallay E, Wrba F, Kriwanek S, Peterlik M, Cross HS. Immunocytochemical localization of the extracellular calcium-sensing receptor in normal and malignant human large intestinal mucosa. J Histochem Cytochem 2000;48:595-602.
  168. Gama L, Baxendale-Cox LM, Breitwieser GE. Ca2+-sensing receptors in intestinal epithelium. Am J Physiol Cell Physiol 1997;273:1168-1175.
  169. De Luca F, Baron J. Molecular biology and clinical importance of the Ca2+-sensing receptor. Curr Opin Pediatr 1998;10:435-440.
  170. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 1991;251:1451-1455.
  171. Bostick RM, Potter JD, Fosdick L, Grambsch P, Lampe JW, Wood JR, Louis TA, Ganz R, Grandits G. Calcium and colorectal epithelial cell proliferation: A preliminary randomized, double-blinded, placebo-controlled clinical trial. J Natl Cancer Inst 1993;85:132-141.
  172. Newmark HL, Lipkin M. Calcium, vitamin D, and colon cancer. Cancer Res. 1992 Apr 1;52(7 Suppl):2067s-2070s.
  173. Wargovich MJ, Baer AR. Basic and clinical investigations of dietary calcium in the prevention of colorectal cancer. Prev Med 1989;18:672-679.
  174. Rozen P. An evaluation of rectal epithelial proliferation measurement as biomarker of risk for colorectal neoplasia and response in intervention studies. Eur J Cancer Prev 1992;1:215-224.
  175. Speer G, Cseh K, Mucsi K, Takacs I, Dworak O, Winkler G, Szody R, Tisler A, Lakatos P. Calcium-sensing receptor A986S polymorphism in human rectal cancer. Int J Colorectal Dis 2002;17:20-24.
  176. Berx G, Staes K, van Hengel J, Molemans F, Bussemakers MJ, van Bokhoven A, van Roy F. Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1). Genomics 1995;26:281-289.
  177. Graff JR, Herman JG, Lapidus RG, Chopra H, Xu R, Jarrard DF, Isaacs WB, Pitha PM, Davidson NE, Baylin SB. E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res 1995;55:5195-5199.
  178. Hennig G, Behrens J, Truss M, Frisch S, Reichmann E, Birchmeier W. Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo. Oncogene 1995;11:475-484.
  179. Dorudi S, Sheffield JP, Poulson R, Northover JM, Hart IR. E-cadherin expression in colorectal cancer: An immunochemical and in situ hybridization study. Am J Pathol 1993;142:981-986.
  180. Azarschab P, Porschen R, Gregor M, Blin N, Holzmann K. Epigenetic control of the E-cadherin gene (CDH1) by CpG methylation in colectomy samples of patients with ulcerative colitis. Genes Chromosomes Cancer 2002;35:121-126.
  181. Bedi A, Pasricha PJ, Akhtar AJ, Barber JP, Bedi GC, Giardello FM, Zehnbauer BA, Hamilton SR, Jones RJ. Inhibition of apoptosis during development of colorectal cancer. Cancer Res 1995;55:1811-1816.
  182. Boland CR. The biology of colorectal cancer: Implications for pretreatment and follow-up management. Cancer 1993;71:4180-4186.
  183. Fearon ER. Molecular genetic studies of the adenoma-carcinoma sequence. Adv Intern Med 1994;39:123-147.
  184. Rustgi AK. Molecular genetics and colorectal cancer. Gastroenterology 1993;104:1223-1225.
  185. Greenwald P, Kelloff GJ, Boone CW, McDonald SS. Genetic and cellular changes in colorectal cancer: Proposed targets of chemopreventive agents. Cancer Epidemiol Biomarkers Prev 1995;4:691-702.
  186. Slattery ML, Schaffer D, Edwards SL, Ma K-N, Potter JD. Are dietary factors involved in DNA methylation associated with colon cancer? Nutr Cancer 1997;28:52-62.
  187. Rosty C, Ueki T, Argani P, Jansen M, Yeo CJ, Cameron JL, Hruban RH, Goggins M. Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. Am J Pathol 2002;160:45-50.
  188. Bronckart Y, Decaestecker C, Nagy N, Harper L, Schafer BW, Salmon I, Pochet R, Kiss R, Heizman CW. Development and progression of malignancy in human colon tissues are correlated with expression of specific Ca2+-binding S100 proteins. Histol Histopathol 2001;16:707-712.
  189. Stulik J, Osterreicher J, Koupilova K, Knizek, Macela A, Bures J, Jandik P, Langr F, Dedic K, Jungblut PR. The analysis of S100A9 and S100A8 expression in matched sets of macroscopically normal colon mucosa and colorectal carcinoma: The S100A9 and S100A8 positive cells underlie and invade tumor mass. Electrophoresis 1999;20:1047-1054.
  190. Kristinsson J, Armbruster CH, Ugstad M, Kriwanek S, Nygaard K, Ton H, Fuglerud P. Fecal excretion of calprotectin in colorectal cancer. Relationship to tumor characteristics. Scand J Gastroenterol 2001;36:202-207.
  191. Takenaga K, Nakanishi H, Wada K, Suzuki M, Matsuzaki O, Matsuura A, Endo H. Increased expression of S100A4, a metastasis-associated gene, in human colorectal adenocarcinomas. Clin Cancer Res 1997;3:2309-2316.
  192. Stulik J, Osterreicher J, Koupilova K, Knizek J, Bures J, Jandik P, Langr F, Dedic K, Schafer BW, Heizmann CW. Differential expression of the Ca2+ binding S100A6 protein in normal, preneoplastic and neoplastic colon mucosa. Eur J Cancer 2000;36:1050-1059.
  193. Barraclough R. Calcium-binding protein S100A4 in health and disease. Biochim Biophys Acta 1998;1448:190-199.
  194. Komatsu K, Andoh A, Ishiguro S, Suzuki N, Hunai H, Kobune-Fujiwara Y, Kameyama M, Miyoshi J, Akedo H, Nakamura H. Increased expression of S100A6 (Calcyclin), a calcium-binding protein of the S100 family, in human colorectal adenocarcinomas. Clin Cancer Res 2000;6:172-177.
  195. Summerton CB, Longlands MG, Wiener K, Shreeve DR. Faecal calprotectin: A marker of inflammation throughout the intestinal tract. Eur J Gastroenterol Hepatol 2002;14:841-845.
  196. Gongoll S, Peters G, Mengel M, Piso P, Klempnauer J, Kreipe H, von Wasielewski R. Prognostic significance of calcium-binding protein S100A4 in colorectal cancer. Gastroenterology 2002;123:1478-1484.
  197. Steinbach G, Heymsfield S, Olansen NE, Tighe A, Holt PR. Effect of caloric restriction on colonic proliferation in obese persons: Implications for colon cancer prevention. Cancer Res 1994;54:1194-1197.
  198. Cats A, Kleibeuker JH, van der Meer R, Kuipers F, Sluiter WJ, Hardonk MJ, Oremus ET, Mulder NH, de Vries EG. Randomized, double-blinded, placebo-controlled intervention study with supplemental calcium in families with hereditary nonpolyposis colorectal cancer. J Natl Cancer Inst 1995;87:598-603.
  199. Chadwick VS, Gaginella TS, Carlson GL, Debognie JC, Phillips SF, Hofmann AF. Effect of molecular structure on bile acid-induced alterations in absorptive function, permeability and morphology in the perfused rabbit colon. J Lab Clin Med 1979;94:661-674.
  200. Deschner EE, Cohen BI, Raicht RF. Acute and chronic effect of dietary cholic acid on colonic epithelial cell proliferation. Digestion 1981;21:290-296.
  201. Deschner EE, Raicht RF. Influence of bile on kinetic behavior of colonic epithelial cells of the rat. Digestion 1981;19:322-327.
  202. Koga S, Kaibara N, Takeda R. Effect of bile acids on 1,2-dimethylhydrazine-induced colon cancer in rats. Cancer 1982;50:543-547.
  203. Cohen BI, Raicht RF. Effects of bile acids on colon carcinogenesis in rats treated with carcinogens. Cancer Res 1981;41:3759-3760.
  204. Cruse JP, Lewin MR, Clark CG. The effects of cholic acid and bile salt binding agents on 1,2-dimehylhydrazine induced colon carcinogenesis in the rat. Carcinogenesis 1981;2:439-443.
  205. Reddy BS, Narisawa T, Weisburger JH, Wynder EL. Effect of sodium deoxycholate on colon adenocarcinomas in germ free rats. J Natl Cancer Inst 1976;56:441-442.
  206. Wargovich MJ. Phytic acid, a major calcium chelator from fiber-rich cereals stimulates colonic cellular proliferation (abstract). Gastroenterology 1986;90:1684.
  207. Rafter JJ, Eng VWS, Furrer R, Bruce WR. Effects of calcium and pH on the mucosal damage produced by deoxycholic acid in the rat colon. Gut 1986;27:1320-1329.
  208. Reddy BS, Watanabe K. Effect of cholesterol metabolism and promoting effect of lithocolic acid on colon carcinogenesis in germ-free and conventional F344 rats. Cancer Res 1979;39:1521-1524.
  209. Glauert HP, Bennik MB. Influence of diet or intrarectal bile acid injections on colon epithelial cell proliferation in rats previously injected with 1,2-dimethylhydrazine. J Nutr 1983;113:475-482.
  210. Sakaguchi M, Hiramatsu Y, Takada H, Yamamura M, Hioki K, Saito K, Yamamoto M. Effect of dietary unsaturated and saturated fats on azoxymethane-induced colon carcinogenesis in rats. Cancer Res 1984;44:1472-1477.
  211. Bull AW, Nigro ND, Golembieski WA, Crissman JD, Marnett LJ. In vivo stimulation of DNA synthesis and induction of ornithine decarboxylase in rat colon by fatty acid hydroperoxides, autoxidation products of unsaturated fatty acids. Cancer Res 1984;44:4924-4928.
  212. Silverman SJ, Andrews AW. Bile acids: Co-mutagenic activity in the Salmonella-mammalian-microsome mutagenicity test (Brief communication). J Natl Cancer Inst 1977;59:1557-1559.
  213. Richards TC. Changes in crypt cell populations of mouse colon during recovery from treatment with 1,2-dimethylhydrazine. J Natl Cancer Inst 1981;66:907-912.
  214. Cohen BI, Raicht RF, Deschner EE, Takahashi M, Sarwal AN, Fazzini E. Effect of cholic acid feeding on N-methyl-N-nitrosourea induced colon tumors and cell kinetics in rats. J Natl Cancer Inst 1980;64:573-578.
  215. Nagengast FM, Grubben MJAL, van Munster IP. Role of bile acids in colorectal carcinogenesis. Eur J Cancer 1995;31A:1067-1070.
  216. Lapre JA, de Vries HT, van der Meer R. Dietary calcium phosphate inhibits cytotoxicity of fecal water. Am J Physiol 1991;261:G907-G912.
  217. Newmark HL, Lupton JR. Determinants and consequences of colonic luminal pH: Implications for colon cancer. Nutr Cancer 1990;14:161-173.
  218. Reddy BS. Dietary fat and colon cancer: Animal model studies. Lipids 1992;27:807-813.
  219. Kanazawa K, Konishi F, Mitsuoka T, Terada A, Itoh K, Narushima S, Kumemura M, Kimura H. Factors influencing the development of sigmoid colon cancer. Bacteriologic and biochemical studies. Cancer 1996;77(8 Suppl):1701-1706.
  220. Samelson SL, Nelson RL, Nyhus LM. The protective effect of fecal pH on experimental colon carcinogenesis. J R Soc Med 1985;78:230-233.
  221. Appleton GV, Bristol JB, Williamson RC. Increased dietary calcium and small bowel resection have opposite effects on colonic cell turnover. Br J Surg 1986;73:1018-1021.
  222. Appleton GV, Davies PW, Bristol JB, Williamson RC. Inhibition of intestinal carcinogenesis by dietary supplementation with calcium. Br J Surg. 1987;74:523-525.
  223. Beaty MM, Lee EY, Glauert HP. Influence of dietary calcium and vitamin D on colon epithelial cell proliferation and 1,2-dimethylhydrazine-induced colon carcinogenesis in rats fed high fat diets. J Nutr 1993;123:144-152.
  224. Pence BC, Buddingh F. Inhibition of dietary fat-promoted colon carcinogenesis in rats by supplemental calcium or vitamin D3. Carcinogenesis 1988;9:187-190.
  225. Pereira MA, Barnes LH, Rassman VL, Kelloff GV, Steele VE. Use of azoxymethane-induced foci of aberrant crypts in rat colon to identify potential cancer chemopreventive agents. Carcinogenesis 1994;15:1049-1054.
  226. Vinas-Salas J, Biendicho-Palau P, Pinol-Felis C, Miguelsanz-Garcia S, Perez-Holanda S. Calcium inhibits colon carcinogenesis in an experimental model in the rat. Eur J Cancer 1998;34:1941-1945.
  227. Wang A, Yoshimi N, Tanaka T, Mori H. The inhibitory effect of magnesium hydroxide on the bile acid-induced cell proliferation of colon epithelium in rats in comparison to the action of calcium lactate. Carcinogenesis 1994;15:2661-2663.
  228. Wargovich MJ, Stephens LC, Gray K. Effect of two "human" nutrient density levels of calcium on the promotional phase of colon tumorigenesis in the F344 rat (abstract). Proc Am Assoc Cancer Res 1989;30:196.
  229. Stern HS, Gregoire RC, Kashtan H, Stadler J, Bruce RW. Long-term effects of dietary calcium on risk markers for colon cancer in patients with familial polyposis. Surgery 1990;108:528-533.
  230. van Faassen A, Hazen MJ, van den Brandt PA, van den Bogaard AE, Hermus RJ, Janknegt RA. Bile acids and pH values in total feces and in fecal water from habitually omnivorous and vegetarian subjects. Am J Clin Nutr 1993;58:917-922.
  231. Gregoire RC, Stern HS, Yeung KS, Stadler J, Langley S, Furrer R, Bruce WR. Effect of calcium supplementation on mucosal cell proliferation in high risk patients for colon cancer. Gut 1989;30:376-382.
  232. Govers MJAP, Termont DSML, Lapre JA, Kleibeuker JH, Vonk RJ, Van der Meer R. Calcium in milk products precipitates intestinal fatty acids and secondary bile acids and thus inhibits colonic cytotoxicity in humans. Cancer Res 1996;56:3270-3275.
  233. Behling AR, Greger JL. Mineral metabolism of aging female rats fed various commercially available calcium supplements of yogurt. Pharmacol Res 1988;5:501-505.
  234. Adell-Carceller R, Segarra-Soria M, Gibert-Jerez J, Salvador Sanchis JL, Lazaro-Santander R, Escrig-Sos J, Ruiz-Castillo J. Inhibitory effect of calcium on carcinogenesis at the site of colonic anastomosis: An experimental study. Dis Colon Rectum 1997;40:1376-1381.
  235. Arlow FL, Walczak SM, Luk GD, Majumdar AP. Attenuation of azoxymethane-induced colonic mucosal ornithine decarboxylase and tyrosine kinase activity by calcium in rats. Cancer Res 1989;49:5884-5888.
  236. Barsoum GH, Thompson H, Neoptolemos JP, Keighley MR. Dietary calcium does not reduce experimental colorectal carcinogenesis after small bowel resection despite reducing cellular proliferation. Gut 1992;33:1515-1520.
  237. Behling AR, Kaup SM, Greger JL. Changes in intestinal function of rats initiated with DMH and fed varying levels of butterfat, calcium, and magnesium. Nutr Cancer 1990;13:189-199.
  238. Hambly RJ, Rumney CJ, Cunninghame M, Fletcher JM, Rijken PJ, Rowland IR. Influence of diets containing high and low risk factors for colon cancer on early stages of carcinogenesis in human flora-associated (HFA) rats. Carcinogenesis 1997;18:1535-1539.
  239. Li H, Kramer PM, Lubet RA, Steele VE, Kelloff GJ, Pereira MA. Effect of calcium on azoxymethane-induced aberrant crypt foci and cell proliferation in the colon of rats. Cancer Lett 1998;124:39-46.
  240. Liu Z, Tomotake H, Wan G, Watanabe H, Kato N. Combined effect of dietary calcium and iron on colonic aberrant crypt foci, cell proliferation and apoptosis, and fecal bile acids in 1,2-dimethylhydrazine-treated rats. Oncol Rep 2001;8:893-897.
  241. Molck A-M, Poulsen M, Meyer O. The combination of 1alpha,25(OH2)-vitamin D3, calcium and acetylsalicylic acid affects azoxymethane-induced aberrant crypt foci and colorectal tumours in rats. Cancer Lett 2002;186:19-28.
  242. Nelson RL, Tanure JC, Andrianopoulos G. The effect of dietary milk and calcium on experimental colorectal carcinogenesis. Dis Colon Rectum 1987;30:947-949.
  243. Sitrin MD, Halline AG, Abrahams C, Brasitus TA. Dietary calcium and vitamin D modulate 1,2-dimethylhydrazine-induced colonic carcinogenesis in the rat. Cancer Res 1991;51:5608-5613.
  244. Thiagarajan DG, Bennink MR, Bourquin LD, Kavas FA. Prevention of precancerous colonic lesions in rats by soy flakes, soy flour, genistein, and calcium. Am J Clin Nutr 1998;68(6 Suppl):1394S-1399S.
  245. Behling AR, Kaup SM, Choquette LL, Greger JL. Lipid absorption and intestinal tumor incidence in rats fed on varying levels of calcium and butterfat. Br J Nutr 1990;64:505-513.
  246. Llor X, Jacoby RF, Teng B-B, Davidson NO, Sitrin MD, Brasitus TA. K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: Effects of supplemental dietary calcium and vitamin D deficiency. Cancer Res 1991;51:4305-4309.
  247. Skrypec DJ, Bursey RG. Effect of dietary calcium on azoxymethane-induced intestinal carcinogenesis in male F 344 rats fed high fat diets (abstract). FASEB 1988;2:A857.
  248. Cats A, Mulder NH, de Vries EG, Oremus ET, Kreumer WM, Kleibeuker JH. Calcium phosphate: An alternative calcium compound for dietary prevention of colon cancer? A study on intestinal and faecal parameters in healthy volunteers. Eur J Cancer Prev 1993;2:409-415.
  249. Van der Meer R, Termont DS, De Vries HT. Differential effects of calcium ions and calcium phosphate on cytotoxicity of bile acids. Am J Physiol 1991;260:G142-G147.
  250. Govers MJAP, Van der Meer R. Effects of dietary calcium and phosphate on the intestinal interactions between calcium, phosphate, fatty acids, and bile acids. Gut 1993;34:365-370.
  251. Lapre JA, De Vries HT, Koeman JH, Van der Meer R. The antiproliferative effect of dietary calcium on colonic epithelium is mediated by luminal surfactants and dependent on the type of dietary fat. Cancer Res 1993;53:784-789.
  252. Newmark HL, Wargovich MJ, Bruce WR. Colon cancer and dietary fat, phosphate, and calcium: A hypothesis. J Natl Cancer Inst 1984;72:1323-1325.
  253. Van der Meer R, Kleibeuker JH, Lapre JA. Calcium phosphate, bile acids and colorectal cancer. Eur J Cancer Prev 1991;1(Suppl 2):55-62.
  254. Van der Meer R, Lapre JA, Govers MJ, Kleibeuker JH. Mechanisms of the intestinal effects of dietary fats and milk products on colon carcinogenesis. Cancer Lett 1997;114:75-83.
  255. Wargovich MJ, Allnutt D, Palmer C, Anaya P, Stephens LC. Inhibition of the promotional phase of azoxymethane-induced colon carcinogenesis in the F344 rat by calcium lactate: Effect of simulating two human nutrient density levels. Cancer Lett 1990;53:17-25.
  256. Welberg JW, Kleibeuker JH, Van der Meer R, Kuipers F, Cats A, Van Rijsbergen H, Termont DS, Boersma-van Ek W, Vonk RJ, Mulder NH, de Vries EGE. Effects of oral calcium supplementation on intestinal bile acids and cytolytic activity of fecal water in patients with adenomatous polyps of the colon. Eur J Clin Invest 1993;23:63-68.
  257. Lapre JA, de Vries HT, Termont DSML, Kleibeuker JH, de Vries EGE, van der Meer R. Mechanism of the protective effect of supplemental dietary calcium on cytolytic activity of fecal water. Cencer Res 1993;53:248-253.
  258. van der Meer R, Welberg JW, Kuipers F, Kleibeuker JH, Mulder NH, Termont DSML, Vonk RJ, de Vries HT, de Vries EGE. Effects of supplemental dietary calcium on the intestinal association of calcium phosphate and bile acids. Gastroenterology 1990;99:1653-1659.
  259. Pence BC, Dunn DM, Zhao C, Patel V, Hunter S, Landers M. Protective effects of calcium from nonfat dried milk against colon carcinogenesis in rats. Nutr Cancer 1996;25:35-45.
  260. Appleton GV, Owen RW, Williamson RC. The effect of dietary calcium supplementation on intestinal lipid metabolism. J Steroid Biochem Mol Biol 1992;42:383-387.
  261. Appleton GV, Owen RW, Wheeler EE, Challacombe DN, Williamson RC. Effect of dietary calcium on the colonic luminal environment. Gut 1991;32:1374-1377.
  262. Lapre JA, De Vries HT, Van der Meer R. Cytotoxicity of fecal water is dependent on the type of dietary fat and is reduced by supplemental calcium phosphate in rats. J Nutr 1993;123:578-585.
  263. Suzuki K, Suzuki K, Mitsuoka T. Effect of low-fat, high-fat, and fiber-supplemented high-fat diets on colon cancer risk factors in feces of healthy subjects. Nutr Cancer 1992;18:63-71.
  264. Haenszel W, Correa P, Cuella C. Social class differences among patients with large bowel cancer in Cali, Columbia. J Natl Cancer Inst 1975;54:1031-1035.
  265. Hill MJ, Drasar BS, Aries V, Crowther JS, Hawksworth G, Williams REO. Bacteria and aetiology of cancer of the large bowel. Lancet 1971;i:95-100.
  266. Hill MJ. Steroid nuclear dehydrogenation and colon cancer. Am J Clin Nutr 1974;27:1475-1480.
  267. Jensen OM, MacLennan R, Wahrendorf J. Diet, bowel function, fecal characteristics, and large bowel cancer in Denmark and Finland. Nutr Cancer 1982;4:5-19.
  268. Mower HF, Ray RM, Shoff R, Stemmermann GN, Nomura A, Glober GA, Kamiyama S, Shimada A, Yamakawa H. Fecal bile acids in two Japanese populations with different colon cancer risks. Cancer Res 1979;39:328-331.
  269. Reddy BS, Hedges AR, Laakso K, Wynder EL. Metabolic epidemiology of large bowel cancer: Fecal bulk and constituents of high-risk North American and low-risk Finnish populations. Cancer 1978;42:2832-2838.
  270. Turjman N, Goodman GT, Jacgar B, Nair PP. Diet, nutrition intake, and metabolism in populations at high and low risk for colon cancer: Metabolism of bile acids. Am J Clin Nutr 1984;40:937-941.
  271. Alberts DS, Ritenbaugh C, Story JA, Aickin M, Rees-McGee S, Buller MK, Atwood J, Phelps J, Ramanujam PS, Bellapravalu S, Patel J, Bextinger L, Clark L. Randomized, double-blinded, placebo-controlled study of effect of wheat bran fiber and calcium on fecal bile acids in patients with resected adenomatous colon polyps. J Natl Cancer Inst 1996;88:81-92.
  272. Lupton JR, Steinbach G, Chang WC, O'Brien BC, Wiese S, Stoltzfus CL, Glober GA, Wargovich MJ, McPherson RS, Winn RJ. Calcium supplementation modifies the relative amounts of bile acids in bile and affects key aspects of human colon physiology. J Nutr 1996;126:1421-1428.
  273. Alder RJ, McKeown-Eyssen G, Bright-See E. Randomized trial of the effect of calcium supplementation on fecal risk factors for colorectal cancer. Am J Epidemiol 1993;138:804-814.
  274. Lipkin M, Newmark H. Effect of added dietary calcium on colonic epithelial-cell proliferation in subjects at high risk for familial colonic cancer. N Engl J Med 1985;313:1381-1384.
  275. van Gorkom BA, van der Meer R, Karrenbeld A, van der Sluis T, Zwart N, Termont DS, Boersma-van Ek W, de Vries EG, Kleibeuker JH. Calcium affects biomarkers of colon carcinogenesis after right hemicolectomy. Eur J Clin Invest 2002;32:693-699.
  276. Welberg JW, Monkelbaan JF, de Vries EG, Muskiet FA, Cats A, Oremus ET, Boersma-van Ek W, van Rijsbergen H, van der Meer R, Mulder NH, Kleibeuker JH. Effects of supplemental dietary calcium on quantitative and qualitative fecal fat excretion in man. Ann Nutr Metab 1994;38:185-191.
  277. Little J, Owen RW, Fernandez F, Hawtin PG, Hill MJ, Logan RF, Thompson MH, Hardcastle JD. Asymptomatic colorectal neoplasia and fecal characteristics: A case-control study of subjects participating in the Nottingham fecal occult blood screening trial. Dis Colon Rectum 2002;45:1233-1241.
  278. Geltner-Allinger U, Brismar B, Reinholt FP, Andersson G, Rafter JJ. Soluble fecal acidic lipids and colorectal epithelial cell proliferation in normal subjects and in patients with colon cancer. Scand J Gastroenterol 1991;26:1069-1074.
  279. Hofstad B, Vatn MH, Andersen SN, Owen RW, Larsen S, Osnes M. The relationship between faecal bile acid profile with or without supplementation with calcium and antioxidants on recurrence and growth of colorectal polyps. Eur J Cancer Prev 1998;7:287-294.
  280. van Munster IP, Tangerman A, de Haan AF, Nagengast FM. A new method for the determination of the cytotoxicity of bile acids and aqueous phase of stool: The effect of calcium. Eur J Clin Invest 1993;23:773-777.
  281. Glinghammar B, Venturi M, Rowland IR, Rafter JJ. Shift from a dairy product-rich to a dairy product-free diet: Influence on cytotoxicity and genotoxicity of fecal water - potential risk factors for colon cancer. Am J Clin Nutr 1997;66:1277-1282.
  282. Pence BC. Role of calcium in colon cancer prevention: Experimental and clinical studies. Mutat Res 1993;290:87-95.
  283. Richter F, Newmark HL, Richter A, Leung D, Lipkin M. Inhibition of Western-diet induced hyperproliferation and hyperplasia in mouse colon by two sources of calcium. Carcinogenesis 1995;16:2685-2689.
  284. Rozen P, Liberman V, Lubin F, Angel S, Owen R, Trostler N, Shkolnik T, Kritchevsky D. A new dietary model to study colorectal carcinogenesis: Experimental design, food preparation, and experimental findings. Nutr Cancer 1996;25:79-100.
  285. Nobre-Leitao C, Chaves P, Fidalgo P, Cravo M, Gouveia-Oliveira A, Ferra MA, Mira FC. Calcium regulation of colonic crypt cell kinetics: Evidence for a direct effect in mice. Gastroenterology 1995;109:498-504.
  286. Belleli A, Shany S, Levy J, Guberman R, Lamprecht SA. A protective role of 1,25-dihydroxyvitamin D3 in chemically induced rat colon carcinogenesis. Carcinogenesis 1992;13:2293-2298.
  287. Barthold SW, Beck D. Modification of early dimethylhydrazine carcinogenesis by colonic mucosa hyperplasia. Cancer Res 1980;40:4451-4455.
  288. Yu B, Wu J, Zhou X. [Interference of selenium germanium and calcium in carcinogenesis of colon cancer.] Zhonghua Wai Ke Za Zhi 1995;33:167-169.
  289. Ahnen J. Are animal models of colon cancer relevant to human diseases? Dig Dis Sci 1985;30:103S-106S.
  290. Chang WWL. Histogenesis of colon cancer in experimental animals. Scand J Gastroenterol 1984;19(Suppl. 104):27-43.
  291. Ranhotra GS, Gelroth JA, Glaser BK, Schoening P, Brown SE. Cellulose and calcium lower the incidence of chemically-induced colon tumors in rats. Plant Foods Hum Nutr 1999;54:295-303.
  292. Potten CS, Loeffler M. Stem cells: Attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 1990;110:1001-1020.
  293. Comer PF, Clark TD, Glauert HP. Effect of dietary vitamin D3 (cholecalciferol) on colon carcinogenesis induced by 1,2-dimethylhydrazine in male Fischer 344 rats. Nutr Cancer 1993;19:113-124.
  294. Tao L, Kramer PM, Wang W, Yang S, Lubet RA, Steele VE, Pereira MA. Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents. Carcinogenesis 2002;23:1447-1454.
  295. Pence BC, Dunn DM, Zhao C, Landers M, Wargovich MJ. Chemopreventive effects of calcium but not aspirin supplementation in cholic acid-promoted colon carcinogenesis: Correlation with intermediate endpoints. Carcinogenesis 1995;16:757-765.
  296. Wargovich MJ, Jimenez A, McKee K, Steele VE, Velasco M, Woods J, Price R, Gray K, Kelloff GJ. Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression. Carcinogenesis 2000;21:1149-1155.
  297. Wargovich MJ, Chen CD, Jimenez A, Steele VE, Velasco M, Stephens LC, Price R, Gray K, Kelloff GJ. Aberrant crypts as a biomarker for colon cancer: Evaluation of potential chemopreventive agents in the rat. Cancer Epidemiol Biomarkers Prev 1996;5:355-360.
  298. Belbraouet S, Felden F, Pelletier X, Gastin I, Lambert D, Floquet J, Gueant JL, Debry G. Dietary calcium salts as protective agents and laminin P1 as a biochemical marker in chemically induced colon carcinogenesis in rats. Cancer Detect Prev 1996;20:294-299.
  299. McSherry CK, Cohen BI, Bokkenheuser VD, Mosbach EH, Winter J, Matoba N, Scholes J. Effects of calcium and bile acid feeding on colon tumors in the rat. Cancer Res 1989;49:6039-6043.
  300. Quilliot D, Belbraouet S, Pelletier X, Gueant JL, Floquet J, Debry G. Influence of a high-calcium carbonate diet on the incidence of experimental colon cancer in rats. Nutr Cancer 1999;34:213-219.
  301. Reshef R, Rozen P, Fireman Z, Fine N, Barzilai M, Shasha SM, Shkolnik T. Effect of a calcium-enriched diet on the colonic epithelial hyperproliferation induced by N-methyl-N'-nitro-N-nitroso-guanidine in rats on a low calcium and fat diet. Cancer Res 1990;50:1764-1767.
  302. Weisburger JH, Rivenson A, Hard GC, Zang E, Nagao M, Sugimura T. Role of fat and calcium in cancer causation by food mutagens, heterocyclic amines. Proc Soc Exp Biol Med 1994;205:347-352.
  303. Bird RP. Effect of dietary components on the pathobiology of colonic epithelium: Possible relationship with colon tumorigenesis. Lipids 1986;21:289-291.
  304. Sesink AL, Termont DS, Kleibeuker JH, Van der Meer R. Red meat and colon cancer: Dietary haem-induced colonic cytotoxicity and epithelial hyperproliferation are inhibited by calcium. Carcinogenesis 2001;22:1653-1659.
  305. Nundy S, Malamud D, Obeertrop H, Sczerban J, Malt RA. Onset of cell proliferation in the shortened gut: Colonic hyperplasia after ileal resection. Gastroenterology 1977;72:263-266.
  306. Williamson RCN, Bauer FLR, Ross JS, Malt RA. Proximal enterectomy stimulates distal hyperplasia more than bypass or pancreato-biliary diversion. Gastroenterology 1978;74:16-23.
  307. Rainey JB, Davies PW, Williamson RCN. Relative effects of ileal resection and bypass on intestinal adaptation and carcinogenesis. Br J Surg 1984;71:197-202.
  308. Scudamore CH, Freeman HJ. Effects of small bowel transection, or bypass in 1,2-dimethylhydrazine induced rat intestinal neoplasia. Gastroenterology 1983;84:725-731.
  309. Williamson RCN, Bauer FLR, Terpstra OT, Ross JS, Malt RA. Contrasting effects of subtotal enteric bypass, enterectomy, and colectomy on azoxymethane-induced intestinal carcinogenesis. Cancer Res 1980;40:538-543.
  310. Bristol JB, Wells M, Williamson RCN. Adaptation to jejunoileal bypass promotes experimental colorectal carcinogenesis. Br J Surg 1984;71:123-126.
  311. Terpstra OT, Dahl EP, Williamson RCN, Ross JS, Malt RA. Colostomy closure promotes cell proliferation and dimethylhydrazine-induced carcinogenesis in rat distal colon. Gastroenterology 1981;81:475-480.
  312. Williamson RCN, Bauer FLR, Ross JS, Watkins JB, Malt RA. Enhanced colonic carcinogenesis with azoxymethane in rat after pancreatobiliary diversion in mid small bowel. Gastroenterology 1979;76:1386-1392.
  313. Rainey JB, Maeda M, Williamson RCN. The tropic effect of intrarectal deoxycholate on rat colorectum is unaffected by oral metronidazole. Cell Tissue Kinet 1986;19:485-490.
  314. Williamson RCN, Rainey JB. The relationship between intestinal hyperplasia and carcinogenesis. Scand J Gastroenterol 1984;19(Suppl. 104):57-76.
  315. Harte PJ, Steele G Jr, Rayner AA, Munroe AE, King VP, Wilson RE. Effect of major small bowel resection on dimethylhydrazine-induced bowel carcinogenesis. J Surg Oncol 1981;18:87-93.
  316. Williamson RCN, Bauer FLR, Oscarson JEA, Ross JS, Malt RA. Promotion of azoxymethane-induced colonic neoplasia by resection of the proximal small bowel. Cancer Res 1978;38:3212-3217.
  317. Lipkin M. Biomarkers of increased susceptibility to gastrointestinal cancer: New applications to studies of cancer prevention in human subjects. Cancer Res 1988;48:235-245.
  318. Wargovich MJ, Lointier PH. Calcium and vitamin D modulate mouse colon epithelial proliferation and growth characteristics of a human colon tumor cell line. Can J Physiol Pharmacol 1987;65:472-477.
  319. Penman ID, Liang QL, Bode J, Eastwood MA, Arends MJ. Dietary calcium supplementation increases apoptosis in the distal murine colonic epithelium. J Clin Pathol 2000;53:302-307.
  320. Hambly RJ, Saunders M, Rijken PJ, Rowland IR. Influence of dietary components associated with high or low risk of colon cancer on apoptosis in the rat colon. Food Chem Toxicol 2002;40:801-808.
  321. Preston-Martin S, Pike MC, Ross RK, Jones PA, Henderson BE. Increased cell division as a cause of human cancer. Cancer Res 1990;50:7415-7421.
  322. Ames BN, Gold LS, Willett WC. The causes and prevention of cancer. PNAS USA 1995;92:5258-5265.
  323. Lipkin M, Blattner WE, Fraumeni JF Jr, Lynch HT, Deschner E, Winawer S. Tritiated thymidine (øp, øh) labeling distribution as a marker for hereditary predisposition to colon cancer. Cancer Res 1983;43:1899-1904.
  324. Ponz de Leon M, Roncucci L, Di Donato P, Tassi L, Smerieri O, Grazia M, Malagoli AG, De Maria D, Antonioli A, Chahin N, Perini M, Rigo G, Barberini G, Manenti A, Biasco G, Barbara L. Pattern of epithelial cell proliferation in colorectal mucosa of normal subjects and of patients with adenomatous polyps or cancer of the large bowel. Cancer Res 1988;48:4121-4126.
  325. Scalmati A, Lipkin M. Intermediate biomarkers of increased risk for colorectal cancer: Comparison of different methods of analysis and modifications by chemopreventive interventions. J Cell Biochem Suppl 1992;16G:65-71.
  326. Palmieri GMA. Dietary calcium and colonic cancer (letter). N Engl J Med 1986;314:1388.
  327. Anti M, Marra G, Armelao F, Percesepe A, Ficarelli R, Ricciuto GM, Valenti A, Rapaccini GL, de Vitis I, D'Agostino G, Brighi S, Vecchio FM. Rectal epithelial cell proliferation patterns as predictors of adenomatous colorectal polyp recurrence. Gut 1993;34:525-530.
  328. Bleiberg H, Buyse M, Galand P. Cell kinetic indicators of premalignant stages of colorectal cancer. Cancer 1985;56:124-129.
  329. Lipkin M, Blattner WA, Gardner EJ, Burt RW, Lynch H, Deschner E, Winawer S, Fraumeni JF Jr. Classification and risk assessment of individuals with familial polyposis, Gardner's syndrome and familial non-polyposis colon cancer from [3H]thymidine labeling patterns in colonic epithelial cells. Cancer Res 1984;44:4201-4207.
  330. Lipkin M, Enker WE, Winawer SJ. Tritiated-thymidine labeling of rectal epithelial cells in "non-prep" biopsies of individuals at increased risk for colonic neoplasia. Cancer Lett 1987;37:153-161.
  331. Lipkin M, Uehara K, Winawer S, Sanchez A, Bauer C, Phillips R, Lynch HT, Blattner WA, Fraumeni JF Jr. Seventh-Day Adventist vegetarians have quiescent proliferative activity in colonic mucosa. Cancer Lett 1985;26:139-144.
  332. Paganelli GM, Biasco G, Santucci R, Brandi G, Lalli AA, Miglioli M, Barbara L. Rectal cell proliferation and colorectal cancer risk level in patients with nonfamilial adenomatous polyps of the large bowel. Cancer 1991;68:2451-2454.
  333. Risio M, Lipkin M, Candelaresi G, Bertone A, Coverlizza S, Rossini FP. Correlations between rectal mucosa cell proliferation and the clinical and pathological features of nonfamilial neoplasia of the large intestine. Cancer Res 1991;51:1917-1921.
  334. Rooney PS, Clarke PA, Gifford KA, Hardcastle JD, Armitage NC. Identification of high and low risk groups of colorectal cancer using rectal mucosal crypt cell production rate (CCPR). Br J Cancer 1993;68:172-175.
  335. Scalmati A, Roncucci L, Ghidini G, Biasco G, Ponz de Leon M. Epithelial cell kinetics in the remaining colorectal mucosa after surgery for cancer of the large bowel. Cancer Res 1990;50:7937-7941.
  336. Stadler J, Yeung KS, Furrer R, Marcon N, Himal HS, Bruce WR. Proliferative activity of rectal mucosa and soluble fecal bile acids in patients with normal colons and in patients with colonic polyps or cancer. Cancer Lett 1988;38:315-320.
  337. Terpstra OT, van Blankenstein M, Dees J, Eilers GAM. Abnormal pattern of cell proliferation in the entire colonic mucosa of patients with colon adenoma or cancer. Gastroenterology 1987;92:704-708.
  338. Welberg JW, de Vries EG, Hardonk MJ, Mulder NH, Harms G, Grond J, Zwart N, Koudstaal J, de Ley L, Kleibeuker JH. Proliferation rate of colonic mucosa in normal subjects and patients with colonic neoplasms: A refined immunohistochemical method. J Clin Pathol 1990;43:453-456.
  339. Barsoum GH, Hendrickse C, Winslet MC, Youngs D, Donovan IA, Neoptolemos JP, Keighley MR. Reduction of mucosal crypt cell proliferation in patients with colorectal adenomatous polyps by dietary calcium supplementation. Br J Surg 1992;79:581-583.
  340. Deschner EE, Lewis DM, Lipkin M. In vitro study of human rectal epithelial cells. 1. Atypical zone of H3 thymidine incorporation in mucosa of multiple polyposis. J Clin Invest 1963;42:1922-1928.
  341. Riddell RH. Dysplasia and cancer in ulcerative colitis: A soluble problem? Scand J Gastroenterol 1984;19 (Suppl. 104):137-149.
  342. Biasco G, Lipkin M, Minarini A, Higgins P, Miglioli M, Barbara L. Proliferative and antigenic properties of rectal cells in patients with chronic ulcerative colitis. Cancer Res 1984;44:5450-5454.
  343. Bleiberg H, Mainguet P, Galand P, Chretien J, Dupont-Mairesse M. Cell renewal in the human rectum: In vitro autoradiographic study on active ulcerative colitis. Gastroenterology 1970;58:851-855.
  344. Deschner EE, Winawer SJ, Katz S, Katzka I, Kahn E. Proliferation defects in ulcerative colitis patients. Cancer Invest 1983;1:41-47.
  345. Gerdes H, Gillin JS, Zimbalist E, Urmacher C, Lipkin M, Winawer SJ. Expansion of the epithelial proliferative compartment and frequency of adenomatous polyps in the colon correlate with strength of family history of colorectal cancer. Cancer Res 1993;53:279-282.
  346. Paganelli GM, Santucci R, Biasco G, Miglioli M, Barbara L. Effect of sex and age on rectal cell renewal in humans. Cancer Lett 1990;53:117-121.
  347. Roncucci L, Ponz de Leon M, Scalmati A, Malgoli G, Pratissoli S, Perini M, Chalin NJ. The influence of age on colonic epithelial cell proliferation. Cancer 1988;62:2373-2377.
  348. Risio M, Coverlizza M, Ferrari A, Candelaresi G, Rossini F. Immunohistochemical study of epithelial cell proliferation in hyperplastic polyps, adenomas, and adenocarcinomas of the large bowel. Gastroenterology 1988;94:899-906.
  349. Anti M, Marra G, Armelao F, Bartoli GM, Ficarelli R, Percesepe A, de Vitis I, Maria G, Sofo L, Rapaccini GL, Gentiloni N, Piccioni E, Miggiano G. Effect of O-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer. Gastroenterology 1992;103:883-891.
  350. Biasco G, Zannoni U, Paganelli GM, Santucci R, Gionchetti P, Rivolta G, Miniero R, Pironi L, Calabrese C, Di Febo G, Miglioli M. Folic acid supplementation and cell kinetics of rectal mucosa in patients with ulcerative colitis. Cancer Epidemiol Biomarkers Prev 1997;6:469-471.
  351. Cascinu S, Del Ferro E, Grianti C, Foglietti GP, Olivieri Q, Bartolucci M, Saba V, Lungarotti F, Catalano G. Hyperproliferative status of the epithelium in the remaining colorectal mucosa after surgery for cancer of the large bowel: Its implications in the prediction of adenomatous polyps recurrence. GI Cancer 1995;1:119-122.
  352. Nakamura S, Kino I, Baba S. Nuclear DNA content of isolated crypts of background colonic mucosa from patients with familial adenomatous polyposis and sporadic colorectal cancer. Gut 1993;34:1240-1244.
  353. Wargovich MJ, Harris C, Chen D, Palmer C, Steele VE, Kelloff GJ. Growth kinetics and chemoprevention of aberrant crypts in the rat colon. J Cell Biochem 1992;(Suppl. 16G):51-54.
  354. Potten CS, Kellett M, Roberts SA, Rew DA, Wilson GD. Measurement of in vivo proliferation in human colorectal mucosa using bromodeoxyuridine. Gut 1992;33:71-81.
  355. Morgan JW, Singh PN. Diet, body mass index and colonic epithelial cell proliferation in a healthy population. Nutr Cancer 1995;23:247-257.
  356. Sandler RS, Baron JA, Tosteson TD, Mandel JS, Haile RW. Rectal mucosal proliferation and risk of colorectal adenomas: Results from a randomized controlled trial. Cancer Epidemiol Biomarkers Prev 2000;9:653-656.
  357. Armitage NC, Rooney PS, Gifford K-A, Clarke PA, Hardcastle JD. The effect of calcium supplements on rectal mucosal proliferation. Br J Cancer 1995;71:186-190.
  358. Bostick RM, Fosdick L, Wood JR, Grambsch P, Grandits GA, Lillemoe TJ, Louis TA, Potter JD. Calcium and colorectal epithelial cell proliferation in sporadic adenoma patients: A randomized, double-blinded, placebo-controlled clinical trial. J Natl Cancer Inst 1995;87:1307-1315.
  359. Thomas MG, Thomason JPS, Williamson RCN. Oral calcium inhibits rectal epithelial cell proliferation in familial adenomatous polyposis. Br J Surg 1993;80:499-501.
  360. Lipkin M, Friedman E, Winawer SJ, Newmark H. Colonic epithelial cell proliferation in responders and nonresponders to supplemental dietary calcium. Cancer Res 1989;49:248-254.
  361. Lipkin M, Newmark H. Application of intermediate biomarkers and the prevention of cancer of the large intestine. Prog Clin Biol Res 1988;279:135-150.
  362. Holt PR, Wolper C, Moss SF, Yang K, Lipkin M. Comparison of calcium supplementation or low-fat dairy foods on epithelial cell proliferation and differentiation. Nutr Cancer 2001;41:150-155.
  363. O'Sullivan KR, Mathias PM, Beattie S, O'Morain C. Effect of oral calcium supplementation on colonic crypt cell proliferation in patients with adenomatous polyps of the large bowel. Eur J Gastroenterol Hepatol 1993;5:85-89.
  364. Rozen P, Fireman Z, Fine N, Wax Y, Ron E. Oral calcium suppresses increased rectal epithelial proliferation of persons at risk of colorectal cancer. Gut 1989;30:650-655.
  365. Wargovich MJ, Isbell G, Shabot M, Winn R, Lanza F, Hochman L, Larson E, Lynch P, Roubein L, Levin B. Calcium supplementation decreases rectal epithelial cell proliferation in subjects with sporadic adenoma. Gastroenterology 1992;103:92-97.
  366. Rozen P, Lubin F, Papo N, Knaani J, Farbstein H, Farbstein M, Zajicek G. Calcium supplements interact significantly with long-term diet while suppressing rectal epithelial proliferation of adenoma patients. Cancer 2001;91:833-840.
  367. Rozen P, Lubin F, Papo N, Zajicek G. Rectal epithelial proliferation in persons with or without a history of adenoma and its association with diet and lifestyle habits. Cancer 1998;83:1319-1327.
  368. Lans JI, Jaszewski R, Arlow FL, Tureaud J, Luk GD, Majumdar AP. Supplemental calcium suppresses colonic mucosal ornithine decarboxylase activity in elderly patients with adenomatous polyps. Cancer Res 1991;51:3416-3419.
  369. Bartram H-P, Kasper K, Dusel G, Liebscher E, Gostner A, Loges C, Scheppach W. Effects of calcium and deoxycholic acid on human colonic cell proliferation in vitro. Ann Nutr Metab 1997;41:315-323.
  370. Guo Y-S, Draviam E, Townsend CM Jr, Singh P. Differential effects of Ca2+ on proliferation of stomach, colonic, and pancreatic cancer cell lines in vitro. Nutr Cancer 1990;14:149-157.
  371. Hulla W, Kallay E, Krugluger W, Peterlik M, Cross HS. Growth control of human colon-adenocarcinoma-derived Caco-2 cells by vitamin-D compounds and extracellular calcium in vitro: Relation to c-myc-oncogene and vitamin-D-receptor expression. Int J Cancer 1995;62:711-716.
  372. Baron JA, Tosteson TD, Wargovich MJ, Sandler R, Mandel J, Bond J, Haile R, Summers R, van Stolk R, Rothstein R, Weiss J. Calcium supplementation and rectal mucosal proliferation: A randomized controlled trial. J Natl Cancer Inst 1995;87:1303-1307.
  373. Weisgerber UM, Boeing H, Owen RW, Waldherr R, Raedsch R, Wahrendorf J. Effect of longterm placebo controlled calcium supplementation on sigmoidal cell proliferation in patients with sporadic adenomatous polyps. Gut 1996;38:396-402.
  374. Alberts DS, Einspahr J, Ritenbaugh C, Aickin M, Rees-McGee S, Atwood J, Emerson S, Mason-Liddil N, Bettinger L, Patel J, Bellapravalu S, Ramanujam PS, Phelps J, Clark L. The effect of wheat bran fiber and calcium supplementation on rectal mucosal proliferation rates in patients with resected adenomatous colorectal polyps. Cancer Epidemiol Biomarkers Prev 1997;6:161-169.
  375. van Gorkom BAP, Karrenbeld A, van der Sluis T, Zwart N, van der Meer R, de Vries EGE, Kleibeuker JH. Calcium or resistant starch does not affect colonic epithelial cell proliferation throughout the colon in adenoma patients: A randomized controlled trial. Nutr Cancer 2002;43:31-38.
  376. Bostick RM, Boldt M, Darif M, Wood JR, Overn P, Potter JD. Calcium and colorectal epithelial cell proliferation in ulcerative colitis. Cancer Epidemiol Biomarkers Prev 1997;6:1021-1027.
  377. Cascinu S, Ligi M, Del Ferro E, Foglietti G, Cioccolini P, Staccioli MP, Carnevali A, Luigi Rocchi MB, Alessandroni P, Giordani P, Catalano V, Polizzi V, Agostinelli R, Muretto P, Catalano G. Effects of calcium and vitamin supplementation on colon cell proliferation in colorectal cancer. Cancer Invest 2000;18:411-416.
  378. Karagas MR, Tosteson TD, Greenberg ER, Rothstein RI, Roebuck BD, Herrin M, Ahnen D. Effects of milk and milk products on rectal mucosal cell proliferation in humans. Cancer Epidemiol Biomarkers Prev 1998;7:757-766.
  379. Kleibeuker JH, Welberg JW, Mulder NH, van der Meer R, Cats A, Limburg AJ, Kreumer WMT, Hardonk MJ, de Vries EGE. Epithelial cell proliferation in the human sigmoid colon of patients with adenomatous polyps increases during oral calcium supplementation. Br J Cancer 1993;67:500-503.
  380. Duris I, Hruby D, Pekarkova B, Huorka M, Cernakova E, Bezayova T, Ondrejka P. Calcium chemoprevention in colorectal cancer. Hepatogastroenterology 1996;43:152-154.
  381. Almendingen K, Hofstad B, Vatn MH. Lifestyle-related factors and colorectal polyps: Preliminary results from a Norwegian follow-up and intervention study. Eur J Cancer Prev 2002;11:153-158.
  382. Baron JA, Beach M, Mandel JS, van Stolk RU, Haile RW, Sandler RS, Rothstein R, Summers RW, Snover DC, Beck GJ, Frankl H, Pearson L, Bond JH, Greenberg ER. Calcium supplements and colorectal adenomas. Polyp Prevention Study Group. Ann N Y Acad Sci 1999;889:138-145.
  383. Hofstad B, Almendingen K, Vatn M, Andersen SN, Owen RW, Larsen S, Osnes M. Growth and recurrence of colorectal polyps: A double-blind 3-year intervention with calcium and antioxidants. Digestion 1998;59:148-156.
  384. Pietinen P, Malila N, Virtanen M, Hartman TJ, Tangrea JA, Albanes D, Virtamo J. Diet and risk of colorectal cancer in a cohort of Finnish men. Cancer Causes Control 1999;10:387-396.
  385. McCullough ML, Robertson AS, Rodriguez C, Jacobs EJ, Chao A, Carolyn J, Calle EE, Willett WC, Thun MJ. Calcium, vitamin D, dairy products, and risk of colorectal cancer in the cancer prevention study II nutrition cohort (United States). Cancer Causes Control 2003;14:1-12.
  386. Terry P, Baron JA, Bergkvist L, Holmberg L, Wolk A. Dietary calcium and vitamin D intake and risk of colorectal cancer: A prospective cohort study in women. Nutr Cancer 2002;43:39-46.
  387. Zheng W, Anderson KE, Kushi LH, Sellers TA, Greenstein J, Hong CP, Cerhan JR, Bostick RM, Folsom AR. A prospective cohort study of intake of calcium, vitamin D, and other micronutrients in relation to incidence of rectal cancer among postmenopausal women. Cancer Epidemiol Biomarkers Prev 1998;7:221-225.
  388. Kato I, Akhmedkhanov A, Koenig K, Toniolo PG, Shore RE, Riboli E. Prospective study of diet and female colorectal cancer: The New York University Women's Health Study. Nutr Cancer 1997;28:276-281.
  389. Garland C, Shekelle RB, Barrett-Connor E, Criqui MH, Rossof AH, Paul O. Dietary vitamin D and calcium and risk of colorectal cancer: A 19-year prospective study in men. Lancet 1985;1:307-309.
  390. Bostick RM, Potter JD, Sellers TA, McKenzie DR, Kushi LH, Folsom AR. Relation of calcium, vitamin D, and dairy food intake to incidence of colon cancer among older women. The Iowa Women's Health Study. Am J Epidemiol 1993;137:1302-1317.
  391. Sellers TA, Bazyk AE, Bostick RM, Kushi LH, Olson JE, Anderson KE, Lazovich D, Folsom AR. Diet and risk of colon cancer in a large prospective study of older women: An analysis stratified on family history (Iowa, United States). Cancer Causes Control 1998;9:357-367.
  392. Faivre J, Boutron MC, Senesse P, Couillault C, Belighiti C, Meny B. Environmental and familial risk factors in relation to the colorectal adenoma--carcinoma sequence: Results of a case-control study in Burgundy (France). Eur J Cancer Prev 1997;6:127-131.
  393. Wu K, Willett WC, Fuchs CS, Colditz GA, Giovannucci EL. Calcium intake and risk of colon cancer in women and men. J Natl Cancer Inst 2002;94:437-446.
  394. Newmark HL, Shiff SJ. Re: Calcium intake and risk of colon cancer in women and men (letter). J Natl Cancer Inst 2003;95:169.
  395. Almendingen K, Trygg K, Larsen S, Hofstad B, Vatn MH. Dietary factors and colorectal polyps: A case-control study. Eur J Cancer Prev 1995;4:239-246.
  396. Nakaji S, Shimoyama T, Wada S, Sugawara K, Tokunaga S, MacAuley D, Baxter D. No preventive effect of dietary fiber against colon cancer in the Japanese population: A cross-sectional analysis. Nutr Cancer 2003;45:156-159.
  397. Arbman G, Axelson O, Ericsson-Begodzki AB, Fredriksson M, Nilsson E, Sjodahl R. Cereal fiber, calcium, and colorectal cancer. Cancer 1992;69:2042-2048.
  398. Marcus PM, Newcomb PA. The association of calcium and vitamin D, and colon and rectal cancer in Wisconsin women. Int J Epidemiol 1998;27:788-793.
  399. Yang G. [Relationship between colorectal cancer and ten inorganic elements.] Zhonghua Yu Fang Yi Xue Za Zhi 1993;27:282-285.
  400. Yang G, Gao Y-T, Ji B-T. [A case-control study on colorectal cancer and dietary fiber and calcium of various sources.] Zhonghua Yu Fang Yi Xue Za Zhi 1994;28:195-198.
  401. Slattery ML, Edwards SL, Boucher KM, Anderson K, Caan BJ. Lifestyle and colon cancer: an assessment of factors associated with risk. Am J Epidemiol 1999;150:869-877.
  402. Kearney J, Giovannucci E, Rimm EB, Ascherio A, Stampfer MJ, Colditz GA, Wing A, Kampman E, Willett WC. Calcium, vitamin D, and dairy foods and the occurrence of colon cancer in men. Am J Epidemiol 1996;143:907-917.
  403. Kampman E, Giovannucci E, van 't Veer P, Rimm E, Stampfer MJ, Colditz GA, Kok FJ, Willett WC. Calcium, vitamin D, dairy foods, and the occurrence of colorectal adenomas among men and women in two prospective studies. Am J Epidemiol 1994;139:16-29.
  404. De Stefani E, Mendilaharsu M, Deneo-Pellegrini H, Ronco A. Influence of dietary levels of fat, cholesterol, and calcium on colorectal cancer. Nutr Cancer 1997;29:83-89.
  405. Ferraroni M, La Vecchia C, D'Avanzo B, Negri E, Franceschi S, Decarli A. Selected micronutrient intake and the risk of colorectal cancer. Br J Cancer 1994;70:1150-1155.
  406. Peters RK, Pike MC, Garabrant D, Mack TM. Diet and colon cancer in Los Angeles County, California. Cancer Causes Control 1992;3:457-473.
  407. Satia-Abouta J, Galanko JA, Martin CF, Potter JD, Ammerman A, Sandler RS. Associations of micronutrients with colon cancer risk in African Americans and whites: Results from the North Carolina Colon Cancer Study. Cancer Epidemiol Biomarkers Prev 2003;12:747-754.
  408. Kune S, Kune GA, Watson LF. Case-control study of dietary etiological factors: The Melbourne Colorectal Cancer Study. Nutr Cancer 1987;9:21-42.
  409. Slattery ML, Potter JD, Sorenson AW. Age and risk factors for colon cancer (United States and Australia): Are there implications for understanding differences in case-control and cohort studies? Cancer Causes Control 1994;5:557-563.
  410. Yang C-Y, Chiu H-F, Chiu J-F, Tsai S-S, Cheng M-F. Calcium and magnesium in drinking water and risk of death from colon cancer. Jpn J Cancer Res 1997;88:928-933.
  411. Yang C-Y, Chiu H-F. Calcium and magnesium in drinking water and risk of death from rectal cancer. Int J Cancer 1998;77:528-532.
  412. Yang C-Y, Hung C-F. Colon cancer mortality and total hardness levels in Taiwan's drinking water. Arch Environ Contam Toxicol 1998;35:148-151.
  413. Yang C-Y, Tsai S-S, Lai T-C, Hung C-F, Chiu H-F. Rectal cancer mortality and total hardness levels in Taiwan's drinking water. Environ Res 1999;80:311-316.
  414. Slattery ML, Sorenson AW, Ford MH. Dietary calcium intake as a mitigating factor in colon cancer. Am J Epidemiol 1988;128:504-514.
  415. Martinez ME, Marshall JR, Sampliner R, Wilkinson J, Alberts DS. Calcium, vitamin D, and risk of adenoma recurrence (United States). Cancer Causes Control 2002;13:213-220.
  416. Slattery ML, Caan BJ, Potter JD, Berry TD, Coates A, Duncan D, Edwards SL. Dietary energy sources and colon cancer risk. Am J Epidemiol 1997;145:199-210.
  417. Martinez ME, McPherson RS, Levin B, Glober GA. A case-control study of dietary intake and other lifestyle risk factors for hyperplastic polyps. Gastroenterology 1997;113:423-429.
  418. Whelan RL, Horvath KD, Gleason NR, Forde KA, Treat MD, Teitelbaum SL, Bertram A, Neugut AI. Vitamin and calcium supplement use is associated with decreased adenoma recurrence in patients with a previous history of neoplasia. Dis Colon Rectum 1999;42:212-217.
  419. Levi F, Pasche C, Lucchini F, La Vecchia C. Selected micronutrients and colorectal cancer: A case-control study from the canton of Vaud, Switzerland. Eur J Cancer 2000;36:2115-2119.
  420. Whittemore AS, Wu-Williams AH, Lee M, Shu Z, Gallagher RP, Deng-ao J, Lun Z, Xianghui W, Kun C, Jung D, Teh C-Z, Chengde L, Yao XJ, Paffenbarger RS, Henderson BE. Diet, physical activity, and colorectal cancer among Chinese in North America and China. JNCI 1990;82:915-926.
  421. Kampman E, Slattery ML, Caan B, Potter JD. Calcium, vitamin D, sunshine exposure, dairy products and colon cancer risk (United States). Cancer Causes Control 2000;11:459-466.
  422. La Vecchia C, Braga C, Negri E, Franceschi S, Russo A, Conti E, Falcini F, Giacosa A, Montella M, Decarli A. Intake of selected micronutrients and risk of colorectal cancer. Int J Cancer 1997;73:525-530.
  423. Govosdis B, Triantafillidis JK, Chrisochou H, Kalogerakos S, Perdicouris P. Effect of calcium intake on the incidence of sporadic colorectal polyps (letter). Am J Gastroenterol 1994;89:952-953.
  424. White E, Shannon JS, Patterson RE. Relationship between vitamin and calcium supplement use and colon cancer. Cancer Epidemiol Biomarkers Prev 1997;6:769-774.
  425. Wong H-L, Seow A, Arakawa K, Lee H-P, Yu MC, Ingles SA. Vitamin D receptor start codon polymorphism and colorectal cancer risk: Effect modification by dietary calcium and fat in Singapore Chinese. Carcinogenesis 2003;24:1091-1095.
  426. Boyapati SM, Bostick RM, McGlynn KA, Fina MF, Roufail WM, Geisinger KR, Wargovich M, Coker A, Hebert JR. Calcium, vitamin D, and risk for colorectal adenoma: Dependency on vitamin D receptor BsmI polymorphism and nonsteroidal anti-inflammatory drug use? Cancer Epidemiol Biomarkers Prev 2003;12:631-637.
  427. Ma J, Giovannucci E, Pollak M, Chan JM, Gaziano JM, Willett W, Stampfer MJ. Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men. J Natl Cancer Inst 2001;93:1330-1336.
  428. Martinez ME, Giovannucci EL, Colditz GA, Stampfer MJ, Hunter DJ, Speizer FE, Wing A, Willett WC. Calcium, vitamin D, and the occurrence of colorectal cancer among women. J Natl Cancer Inst 1996;88:1375-1382.
  429. Kampman E, Goldbohm RA, van den Brandt PA, van 't Veer P. Fermented dairy products, calcium, and colorectal cancer in The Netherlands Cohort Study. Cancer Res 1994;54:3186-3190.
  430. Gaard M, Tretli S, Loken EB. Dietary factors and risk of colon cancer: A prospective study of 50,535 young Norwegian men and women. Eur J Cancer Prev 1996;5:445-454.
  431. Slob ICM, Lambregts JLMC, Schuit AJ, Kok FJ. Calcium intake and 28-year gastro-intestinal cancer mortality in Dutch civil servants. Int J Cancer 1993;54:20-25.
  432. Hyman J, Baron JA, Dain BJ, Sandler RS, Haile RW, Mandel JS, Mott LA, Greenberg ER. Dietary and supplemental calcium and the recurrence of colorectal adenomas. Cancer Epidemiol Biomarkers Prev 1998;7:291-295.
  433. Stemmermann GN, Nomura A, Chyou P-H. The influence of dairy and nondairy calcium on subsite large-bowel cancer risk. Dis Colon Rectum 1990;33:190-194.
  434. Willett WC, Stampfer MJ, Colditz GA, Rosner BA, Speizer FE. Relation of meat, fat and fiber intake to the risk of colon cancer in a prospective study among women. N Engl J Med 1990;323:1664-1672.
  435. Jarvinen R, Knekt P, Hakulinen T, Aromaa A. Prospective study on milk products, calcium and cancers of the colon and rectum. Eur J Clin Nutr 2001;55:1000-1007.
  436. Malila N, Virtanen M, Pietinen P, Virtamo J, Albanes D, Hartman AM, Heinonen OP. A comparison of prospective and retrospective assessments of diet in a study of colorectal cancer. Nutr Cancer 1998;32:146-153.
  437. Heilbrun LK, Hankin JH, Nomura AM, Stemmermann GN. Colon cancer and dietary fat, phosphorus, and calcium in Hawaiian-Japanese men. Am J Clin Nutr 1986;43:306-309.
  438. Morimoto LM, Newcomb PA, Ulrich CM, Bostick RM, Lais CJ, Potter JD. Risk factors for hyperplastic and adenomatous polyps: Evidence for malignant potential? Cancer Epidemiol Biomarkers Prev 2002;11:1012-1018.
  439. Negri E, La Vecchia C, D'Avanzo B, Franceschi S. Calcium, dairy products, and colorectal cancer. Nutr Cancer 1990;13:255-262.
  440. Pritchard RS, Baron JA, Gerhardsson de Verdier M. Dietary calcium, vitamin D, and the risk of colorectal cancer in Stockholm, Sweden. Cancer Epidemiol Biomarkers Prev 1996;5:897-900.
  441. Levine AJ, Harper JM, Ervin CM, Chen YH, Harmon E, Xue S, Lee ER, Frankel HD, Haile RW. Serum 25-hydroxyvitamin D, dietary calcium intake, and distal colorectal adenoma risk. Nutr Cancer 2001;39:35-41.
  442. Meyer F, White E. Alcohol and nutrients in relation to colon cancer in middle-aged adults. Am J Epidemiol 1993;138:225-236.
  443. Martinez ME, McPherson RS, Annegers JF, Levin B. Association of diet and colorectal adenomatous polyps: Dietary fiber, calcium, and total fat. Epidemiology 1996;7:264-268.
  444. Tseng M, Murray SC, Kupper LL, Sandler RS. Micronutrients and the risk of colorectal adenomas. Am J Epidemiol 1996;144:1005-1014.
  445. Lee HP, Gourley L, Duffy SW, Esteve J, Lee J, Day NE. Colorectal cancer and diet in an Asian population: A case-control study among Singapore Chinese. Int J Cancer 1989;43:1007-1016.
  446. Tuyns AJ, Haelterman M, Kaaks R. Colorectal cancer and the intake of nutrients: Oligosaccharides are a risk factor, fats are not: A case-control study in Belgium. Nutr Cancer 1987;10:181-196.
  447. Freudenheim JL, Graham S, Marshall JR, Haughey BP, Wilkinson G. A case-control study of diet and rectal cancer in western New York. Am J Epidemiol 1990;131:612-624.
  448. Graham S, Marshall J, Haughey B, Mittelman A, Swanson M, Zielezny M, Byers T, Wilkinson G, West D. Dietary epidemiology of cancer of the colon in western New York. Am J Epidemiol 1988;128:490-503.
  449. Macquart-Moulin G, Riboli E, Cornee J, Charnay B, Berthezene P, Day N. Case-control study on colorectal cancer and diet in Marseilles. Int J Cancer 1986;38:183-191.
  450. Benito E, Cabeza E, Moreno V, Obrador A, Bosch FX. Diet and colorectal adenomas: A case-control study in Majorca. Int J Cancer 1993;55:213-219.
  451. Peters U, McGlynn KA, Chatterjee N, Gunter E, Garcia-Closas M, Rothman N, Sinha R. Vitamin D, calcium, and vitamin D receptor polymorphism in colorectal adenomas. Cancer Epidemiol Biomarkers Prev 2001;10:1267-1274.
  452. Macquart-Moulin G, Riboli E, Cornee J, Kaaks R, Berthezene P. Colorectal polyps and diet: A case-control study in Marseilles. Int J Cancer 1987;40:179-188.
  453. Neugut AI, Horvath K, Whelan RL, Terry MB, Garbowski GC, Bertram A, Forde KA, Treat MR, Waye J. The effect of calcium and vitamin supplements on the incidence and recurrence of colorectal adenomatous polyps. Cancer 1996;78:723-728.
  454. Ghadirian P, Lacroix A, Maisonneuve P, Perret C, Potvin C, Gravel D, Bernard D, Boyle P. Nutritional factors and colon carcinoma: A case-control study involving French Canadians in Montreal, Quebec, Canada. Cancer 1997;80:858-864.
  455. Kampman E, van 't Veer P, Hiddink GJ, van Aken-Schneijder P, Kok FJ, Hermus RJ. Fermented dairy products, dietary calcium and colon cancer: A case-control study in The Netherlands. Int J Cancer 1994;59:170-176.
  456. Benito E, Stiggelbout A, Bosch FX, Obrador A, Kaldor J, Mulet M, Munoz N. Nutritional factors in colorectal cancer risk: A case-control study in Majorca. Int J Cancer 1991;49:161-167.
  457. Zaridze D, Filipchenko V, Kustov V, Serdyuk V, Duffy S. Diet and colorectal cancer: Results of two case-control studies in Russia. Eur J Cancer 1993;29A:112-115.
  458. Breuer-Katschinski B, Nemes K, Marr A, Rump B, Leiendecker B, Breuer N, Goebell H. Colorectal adenomas and diet: a case-control study. Colorectal Adenoma Study Group. Dig Dis Sci 2001;46:86-95
  459. Boutron M-C, Faivre J, Marteau P, Couillault C, Senesse P, Quipourt V. Calcium, phosphorus, vitamin D, dairy products and colorectal carcinogenesis: A French case--control study. Br J Cancer 1996;74:145-151.
  460. Peleg II, Lubin MF, Cotsonis GA, Clark WS, Wilcox CM. Long-term use of nonsteroidal antiinflammatory drugs and other chemopreventors and risk of subsequent colorectal neoplasia. Dig Dis Sci 1996;41:1319-1326.
  461. Bonithon-Kopp C, Kronborg O, Giacosa A, Rath U, Faivre J. Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: A randomised intervention trial. European Cancer Prevention Organisation Study Group. Lancet 2000;356:1300-1306.
  462. Slattery ML, Potter JD. Physical activity and colon cancer: Confounding or interaction? Med Sci Sports Exerc 2002;34:913-919.
  463. Wu AH, Paganini-Hill A, Ross RK, Henderson BE. Alcohol, physical activity and other risk factors for colorectal cancer: A prospective study. Br J Cancer 1987;55:687-694.
  464. Bergsma-Kadijk JA, van 't Veer P, Kampman E, Burema J. Calcium does not protect against colorectal neoplasia. Epidemiology 1996;7:590-597.
  465. Wargovich MJ, Lynch PM, Levin B. Modulating effects of calcium in animal models of colon carcinogenesis and short-term studies in subjects at increased risk for colon cancer. Am J Clin Nutr 1991;54(1 Suppl.):202S-205S.
  466. Sandler RS. Epidemiology and risk factors for colorectal cancer. Gastroenterol Clin North Am 1996;25:717-735.
  467. Garland CF, Garland FC, Gorham ED. Calcium and vitamin D. Their potential roles in colon and breast cancer prevention. Ann N Y Acad Sci 1999;889:107-119.
  468. Martinez ME, Willett WC. Calcium, vitamin D, and colorectal cancer: A review of the epidemiologic evidence. Cancer Epidemiol Biomarkers Prev 1998;7:163-168.
  469. Pignone M, Levin B. Recent developments in colorectal cancer screening and prevention. Am Fam Physician 2002;66:297-302.
  470. Gatof D, Ahnen D. Primary prevention of colorectal cancer: Diet and drugs. Gastroenterol Clin North Am 2002;31:587-623.
  471. Anonymous. The role of calcium in peri- and postmenopausal women: Consensus opinion of The North American Menopause Society. Menopause 2001;8:84-95.
  472. Nakhlis F, Morrow M. Ductal carcinoma in situ. Surg Clin North Am 2003;83:821-839.
  473. Adamovich TL, Simmons RM. Ductal carcinoma in situ with microinvasion. Am J Surg 2003;186:112-116.
  474. Graham S, Hellmann R, Marshall J, Freudenheim J, Vena J, Swanson M, Zielezny M, Nemoto T, Stubbe N, Raimondo T. Nutritional epidemiology of postmenopausal breast cancer in western New York. Am J Epidemiol 1991;134:552-566.
  475. Willett W. The search for the causes of breast and colon cancer. Nature 1989;338:389-394.
  476. Singletary SE. Rating the risk factors for breast cancer. Ann Surg 2003;237:474-482.
  477. Welsh J, Wietzke JA, Zinser GM, Smyczek S, Romu S, Tribble E, Welsh JC, Byrne B, Narvaez CJ. Impact of the Vitamin D3 receptor on growth-regulatory pathways in mammary gland and breast cancer. J Steroid Biochem Mol Biol 2002;83:85-92.
  478. Manni A. Polyamine involvement in breast cancer phenotype. In Vivo 2002;16:493-500.
  479. Manni A, Grove R, Kunselman S, Demers L. Involvement of the polyamine pathway in breast cancer progression. Cancer Lett 1995;92:49-57.
  480. Glikman P, Manni A, Demers L, Bartholomew M. Polyamine involvement in the growth of hormone-responsive and -resistant human breast cancer cells in culture. Cancer Res 1989;49:1371-1376.
  481. Manni A. The role of polyamines in the hormonal control of breast cancer cell proliferation. Cancer Treat Res 1994;71:209-225.
  482. Shah N, Thomas TJ, Lewis JS, Klinge CM, Shirahata A, Gelinas C, Thomas T. Regulation of estrogenic and nuclear factor ?B functions by polyamines and their role in polyamine analog-induced apoptosis of breast cancer cells. Oncogene 2001;20:1715-1729.
  483. Thomas T, Gallo MA, Klinge CM, Thomas TJ. Polyamine-mediated conformational perturbations in DNA alter the binding of estrogen receptor to poly(dG-m5dC)?poly(dG-m5dC) and a plasmid containing the estrogen response element. J Steroid Biochem 1995;54:89-99.
  484. Persson L, Rosengren E. Increased formation of N1-acetylspermidine in human breast cancer. Cancer Lett 1989;45:83-86.
  485. Canizares F, Salinas J, de las Heras M, Diaz J, Tovar I, Martinez P, Penafiel R. Prognostic value of ornithine decarboxylase and polyamines in human breast cancer: Correlation with clinicopathologic parameters. Clin Cancer Res 1999;5:2035-2041.
  486. Manni A, Astrow SH, Gammon S, Thompson J, Mauger D, Washington S. Immunohistochemical detection of ornithine decarboxylase in primary and metastatic human breast cancer specimens. Breast Cancer Res Treat 2001;67:147-156.
  487. Leveque J, Bansard JY, Watier E, Catros-Quemener V, Havouis R, Moulinoux JP, Grall JY, Seiler N. Polyamines in human breast cancer and its relations to classical prognostic features: Clinical implications. Anticancer Res 1999;19:2275-2279.
  488. Leveque J, Foucher F, Bansard JY, Havouis R, Grall JY, Moulinoux JP. Polyamine profiles in tumor, normal tissue of the homologous breast, blood, and urine of breast cancer sufferers. Breast Cancer Res Treat 2000;60:99-105.
  489. Leveque J, Foucher F, Havouis R, Desury D, Grall JY, Moulinoux JP. Benefits of complete polyamine deprivation in hormone responsive and hormone resistant MCF-7 human breast adenocarcinoma in vivo. Anticancer Res 2000;20:97-101.
  490. Manni A, Wechter R, Gilmour S, Verderame MF, Mauger D, Demers LM. Ornithine decarboxylase over-expression stimulates mitogen-activated protein kinase and anchorage-independent growth of humam breast epithelial cells. Int J Cancer 1997;70:175-182.
  491. Miller FR, Soule HD, Tait L, Pauley RJ, Wolman SR, Dawson PI, Heppner GH. Xenograft model of progressive human proliferative breast disease. J Natl Cancer Inst 1993;85:1725-1731.
  492. Glikman P, Vegh I, Pollina A, Mosto A, Levy C. Ornithine decarboxylase activity, prolactin blood levels, and estradiol and progesterone in human breast cancer. Cancer 1987;60:2237-2243.
  493. Manni A, Mauger D, Gimotty P, Badger B. Prognostic influence on survival of increased ornithine decarboxylase activity in human breast cancer. Clin Cancer Res 1996;2:1901-1905.
  494. Manni A, Washington S, Griffith JW, Verderame MF, Mauger D, Demers LM, Saman RS, Welch DR. Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cells. Clin Exptl Metastasis 2002;19:95-105.
  495. Manni A, Badger B, Martel J, Demers L. Role of polyamines in the growth of hormone-responsive and -resistant human breast cancer cells in nude mice. Cancer Lett 1992;66:1-9.
  496. Manni A, Wright C. Polyamines as mediators of estrogen action on the growth of experimental breast cancer in rats. J Natl Cancer Inst 1984;73:511-514.
  497. Glikman PI, Manni A, Bartholomew M, Demers L. Polyamine involvement in basal and estradiol stimulated insulin-like growth factor I secretion and action in breast cancer cells in culture. J Steroid Biochem Mol Biol 1990;37:1-10.
  498. Manni A, Badger B, Lynch J, Demers L. Selectivity of polyamine involvement in hormone action on normal and neoplastic target tissues of the rat. Breast Cancer Res Treat 1990;17:187-196.
  499. Thompson HJ, Meeker LD, Herbst EJ, Ronan AM, Minocha R. Effect of concentration of D,1-2-difluoromethylornithine on murine mammary carcinogenesis. Cancer Res 1985;45:1170-1173.
  500. Green JE, Shibata MA, Shibata E, Moon RC, Anver MR, Kelloff G, Lubert R. 2-difluoromethylornithine and dehydroepiandrosterone inhibit mammary tumor progression but not mammary or prostate tumor initiation in C3(1)/SV40 T/t-antigen transgenic mice. Cancer Res 2001;61:7449-7455.
  501. Xue L, Lipkin M, Newmark H, Wang J. Influence of dietary calcium and vitamin D on diet-induced epithelial cell hyperproliferation in mice. J Natl Cancer Inst 1999;91:176-181.
  502. Shin MH, Holmes MD, Hankinson SE, Wu K, Colditz GA, Willett WC. Intake of dairy products, calcium, and vitamin D and risk of breast cancer. J Natl Cancer Inst 2002;94:1301-1311.
  503. Knekt P, Jarvinen R, Seppanen R, Pukkala E, Aromaa A. Intake of dairy products and the risk of breast cancer. Br J Cancer 1996;73:687-691.
  504. Negri E, La Vecchia C, Franceschi S, D'Avanzo B, Talamini R, Parpinel M, Ferraroni M, Filiberti R, Montella M, Falcini F, Conti E, DeCarli A. Intake of selected micronutrients and the risk of breast cancer. Int J Cancer 1996;65:140-144.
  505. Zaridze D, Lifanova Y, Maximovitch D, Day NE, Duffy SW. Diet, alcohol consumption and reproductive factors in a case-control study of breast cancer in Moscow. Int J Cancer 1991;48:493-501.
  506. Boyapati SM, Shu XO, Jin F, Dai Q, Ruan Z, Gao YT, Zheng W. Dietary calcium intake and breast cancer risk among Chinese women in Shanghai. Nutr Cancer 2003;46:38-43.
  507. Van't veer P, van Leer EM, Rietdijk A, Kok FJ, Schouten EG, Hermus RJ, Sturmans F. Combination of dietary factors in relation to breast cancer occurrence. Int J Cancer 1991;47:649-653.
  508. Katsouyanni K, Willett W, Trichopoulos D, Boyle P, Trichopoulou A, Vasilaros S, Papadiamantis J, MacMahon B. Risk of breast cancer among Greek women in relation to nutrient intake. Cancer 1988;61:181-185.
  509. Greenlee RT, Hill-Harmon MB, Murray T, Thun M. Cancer statistics, 2001. CA Cancer J Clin 2001;51:15-36.
  510. Willis MS, Wians FH. The role of nutrition in preventing prostate cancer: A review of the proposed mechanism of action of various dietary substances. Clin Chim Acta 2003;330:57-83.
  511. Vlajinac HD, Marinkovic JM, Ilic MD, Kocev NI. Diet and prostate cancer: A case-control study. Eur J Cancer 1997;33:101-107.
  512. Berndt SI, Carter HB, Landis PK, Tucker KL, Hsieh LJ, Metter EJ, Platz EA. Calcium intake and prostate cancer risk in a long-term aging study: The Baltimore Longitudinal Study of Aging. Urology 2002;60:1118-1123.
  513. Chan JM, Pietinen P, Virtanen M, Malila N, Tangrea J, Albanes D, Virtamo J. Diet and prostate cancer risk in a cohort of smokers, with a specific focus on calcium and phosphorus (Finland). Cancer Causes Control 2000;11:859-867.
  514. Schuurman AG, van den Brandt PA, Dorant E, Goldbohm RA. Animal products, calcium, and protein and prostate cancer risk in the Netherlands Cohort Study. Br J Cancer 1999;80:1107-1113.
  515. Kristal AR, Cohen JH, Qu P, Stanford JL. Associations of energy, fat, calcium, and vitamin D with prostate cancer risk. Cancer Epidemiol Biomarkers Prev 2002;11:719-725.
  516. Tavani A, Gallus S, Franceschi S, La Vecchia C. Calcium, dairy products, and the risk of prostate cancer. Prostate 2001;48:118-121.
  517. Hayes RB, Ziegler RG, Gridley G, Swanson C, Greenberg RS, Swanson GM, Schoenberg JB, Silverman DT, Brown LM, Pottern LM, Liff J, Schwartz AG, Fraumeni JF Jr, Hoover RN. Dietary factors and risk for prostate cancer among blacks and whites in the United States. Cancer Epidemiol Biomarkers Prev 1999;8:25-34.
  518. Kristal AR, Stanford JL, Cohen JH, Wicklund K, Patterson RE. Vitamin and mineral supplement use is associated with reduced risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 1999;8:887-892.
  519. Ohno Y, Yoshida O, Oishi K, Okada K, Yamabe H, Schroeder FH. Dietary beta-carotene and cancer of the prostate: A case-control study in Kyoto, Japan. Cancer Res 1988;48:1331-1336.
  520. Tzonou A, Signorello LB, Lagiou P, Wuu J, Trichopoulos D, Trichopoulou A. Diet and cancer of the prostate: A case-control study in Greece. Int J Cancer 1999;80:704-708.
  521. Zhang Y, Kiel DP, Ellison RC, Schatzkin A, Dorgan JF, Kreger BE, Cupples LA, Felson DT. Bone mass and the risk of prostate cancer: The Framingham Study. Am J Med 2002;113:734-739.
  522. Chan JM, Stampfer MJ, Ma J, Gann PH, Gaziano JM, Giovannucci EL. Dairy products, calcium and prostate cancer risk in the Physicians' Health Study. Am J Clin Nutr 2001;74:549-554.
  523. Giovannucci E, Rimm EB, Wolk A, Ascherio A, Stampfer MJ, Colditz GA, Willett WC. Calcium and fructose intake in relation to risk of prostate cancer. Cancer Res 1998;58:442-447.
  524. Chan JM, Giovannucci E, Anderson S-O, Yuen J, Adami H-O, Wolk A. Dairy products, calcium, phosphorus, vitamin D, and risk of prostate cancer. Cancer Causes Control 1998;9:559-566.
  525. Chan JM, Giovannucci EL. Dairy products, calcium, and vitamin D and risk of prostate cancer. Epidemiol Rev 2001;23:87-92.
  526. Heaney RP, Dowell SD, Bierman J, Hale CA, Bendich A. Absorbability and cost effectiveness in calcium supplementation. J Am Coll Nutr 2001;20:239-246.
  527. Martini L, Wood RJ. Relative bioavailability of calcium-rich dietary sources in the elderly. Am J Clin Nutr 2002;76:1345-1350.
  528. Recker RR. Calcium absorption and achlorhydria. N Engl J Med 1985;313:70-73.
  529. Institute of Medicine. Summary. In: Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. National Academy Press, Washington, DC, 1997, summary.
  530. Institute of Medicine. Uses of dietary reference intakes. In: Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. National Academy Press, Washington, DC, 1997, chapter IX.
  531. Food and Drug Admin istration. Food labeling; health claims; calcium and osteoporosis. Proposed Rule. Fed Reg 1991;56:60689-.
  532. Food and Drug Administration. Food labeling; health claims; calcium and osteoporosis. Final Rule. Fed Reg 1993;58:2665-2677.
  533. Malberti F, Surian M, Poggio F, Minoia C, Salvadeo A. Efficacy and safety of long-term treatment with calcium carbonate as a phosphate binder. Am J Kidney Dis 1988;12:487-491.
  534. Moriniere P, Hocine C, Boudailliez B, Belbrik S, Renaud H, Westeel PF, Solal MC, Fournier A. Long-term efficacy and safety of oral calcium as compared to A1(OH)3 as phosphate binders. Kidney Int 1989;36(Suppl. 27):S133-S135.
  535. Tsukamoto Y, Moriya R, Nagaba Y, Morishita T, Izumida I, Okubo M. Effect of administering calcium carbonate to treat secondary hyperparathyroidism in nondialyzed patients with chronic renal failure. Am J Kidney Dis 1995;25:879-886.
  536. Nolan CR, Qunibi WY. Calcium salts in the treatment of hyperphosphatemia in hemodialysis patients. Curr Opin Nephrol Hypertens 2003;12:373-379.
  537. Clark AGB, Oner A, Ward G, Turner C, Rigden SPA, Haycock GB, Chantler C. Safety and efficacy of calcium carbonate in children with chronic renal failure. Nephrol Dial Transplant 1989;4:539-544.
  538. Orwoll ES. The milk-alkali syndrome: Current concepts. Ann Intern Med 1982;97:242-248.
  539. Adams ND, Gray RW, Lemann J Jr. The effects of oral CaCO3 loading and dietary calcium deprivation on plasma 1,25-dihydroxyvitamin D concentrations in healthy adults. J Clin Endocrinol Metab 1979;48:1008-1016.
  540. Heaney RP, Recker RR. Calcium supplements: Anion effects. Bone Miner 1987;2:433-439.
  541. Lagman R, Walsh D. Dangerous nutrition? Calcium, vitamin D, and shark cartilage nutritional supplements and cancer-related hypercalcemia. Support Care Cancer 2003;11:232-235.
  542. Burtis WJ, Gay L, Insogna KL, Ellison A, Broadus AE. Dietary hypercalciuria in patients with calcium oxalate kidney stones. Am J Clin Nutr 1994;60:424-429.






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This is an INFORMATION ONLY Web Site!
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This is an INFORMATION ONLY Web Site!



This web site is intended to direct the attention of both physician and patient to the torrent of scientific research being carried out on the significance of biological calcium. It is for educational purposes.

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